Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998-2012

被引：75

作者：

van Gent, M. ^{[1
]}

Heuvelman, C. J. ^{[1
]}

van der Heide, H. G. ^{[1
]}

Hallander, H. O. ^{[2
]}

Advani, A. ^{[2
]}

Guiso, N. ^{[3
]}

von Konig, C. H. Wirsing ^{[4
]}

Vestrheim, D. F. ^{[5
]}

Dalby, T. ^{[6
]}

Fry, N. K. ^{[7
]}

Pierard, D. ^{[8
]}

Detemmerman, L. ^{[8
]}

Zavadilova, J. ^{[9
]}

Fabianova, K. ^{[10
]}

Logan, C. ^{[11
]}

Habington, A. ^{[11
]}

Byrne, M. ^{[11
]}

Lutynska, A. ^{[12
]}

Mosiej, E. ^{[12
]}

Pelaz, C. ^{[13
]}

Grondahl-Yli-Hannuksela, K. ^{[14
]}

Barkoff, A. M. ^{[14
]}

Mertsola, J. ^{[15
]}

Economopoulou, A. ^{[16
]}

He, Q. ^{[14
]}

Mooi, F. R. ^{[1
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, Ctr Infect Dis Control CIb, NL-3720 BA Bilthoven, Netherlands

[2] Swedish Natl Inst Publ Hlth, Solna, Sweden

[3] Inst Pasteur, Mol Prevent & Therapy Human Dis, Paris, France

[4] HELIOS Klin, Lab Med Krefeld MVZ, Krefeld, Germany

[5] Norwegian Inst Publ Hlth, Dept Bacteriol & Immunol, Oslo, Norway

[6] Statens Serum Inst, Dept Microbiol & Infect Control, DK-2300 Copenhagen, Denmark

[7] Publ Hlth England Microbiol References Serv, Resp & Vaccine Preventable Bacteria Reference Uni, Colindale, England

[8] Univ Ziekenhuis Brussel, Dept Microbiol & Infect Control, Natl Reference Ctr Pertussis, Brussels, Belgium

[9] Natl Inst Publ Hlth, Natl Reference Lab Pertussis & Diphtheria, Prague, Czech Republic

[10] Natl Inst Publ Hlth, Dept Infect Dis Epidemiol, Prague, Czech Republic

[11] Our Ladys Childrens Hosp, Dept Microbiol, Dublin, Ireland

[12] Natl Inst Hyg, Natl Inst Publ Hlth, Dept Sera & Vaccines Evaluat, PL-00791 Warsaw, Poland

[13] Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain

[14] Natl Inst Hlth & Welf, Dept Infect Dis Surveillance & Control, Turku, Finland

[15] Turku Univ Hosp, Dept Pediat, FIN-20520 Turku, Finland

[16] European Ctr Dis Control & Prevent ECDC, Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2015年 / 34卷 / 04期

关键词：

GEL-ELECTROPHORESIS ANALYSIS; TEMPORAL TRENDS; WHOOPING-COUGH; STRAINS; VACCINATION; PERTACTIN; POPULATIONS; DIVERSITY; EVOLUTION; TOXIN;

D O I：

10.1007/s10096-014-2297-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Despite more than 50 years of vaccination, pertussis is still an endemic disease, with regular epidemic outbreaks. With the exception of Poland, European countries have replaced whole-cell vaccines (WCVs) by acellular vaccines (ACVs) in the 1990s. Worldwide, antigenic divergence in vaccine antigens has been found between vaccine strains and circulating strains. In this work, 466 Bordetella pertussis isolates collected in the period 1998-2012 from 13 European countries were characterised by multi-locus antigen sequence typing (MAST) of the pertussis toxin promoter (ptxP) and of the genes coding for proteins used in the ACVs: pertussis toxin (Ptx), pertactin (Prn), type 2 fimbriae (Fim2) and type 3 fimbriae (Fim3). Isolates were further characterised by fimbrial serotyping, multi-locus variable-number tandem repeat analysis (MLVA) and pulsed-field gel electrophoresis (PFGE). The results showed a very similar B. pertussis population for 12 countries using ACVs, while Poland, which uses a WCV, was quite distinct, suggesting that ACVs and WCVs select for different B. pertussis populations. This study forms a baseline for future studies on the effect of vaccination programmes on B. pertussis populations.

引用

页码：821 / 830

页数：10

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