Lack of association between ATP13A2 Ala746Thr variant and Parkinson's disease in Han population of mainland China

被引：21

作者：

Fei, Qing-Zhou ^{[1
,2
]}

Cao, Li ^{[1
,2
]}

Xiao, Qin ^{[1
,2
]}

Zhang, Ting ^{[1
,2
]}

Zheng, Lan ^{[1
,2
]}

Wang, Xi-Jin ^{[1
,2
]}

Wang, Gang ^{[1
,2
]}

Zhou, Hai-Yan ^{[1
,2
]}

Wang, Ying ^{[1
,2
]}

Chen, Sheng-Di ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Neurol, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Inst Neurol, Shanghai 200025, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Neurodegenerat Dis, Shanghai 200025, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2010年 / 475卷 / 02期

关键词：

Parkinson's disease; ATP13A2; mainland China; P-TYPE ATPASE; JUVENILE PARKINSONISM; ALPHA-SYNUCLEIN; PARTS; MUTATIONS; GENE; EXPOSURE;

D O I：

10.1016/j.neulet.2010.03.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ATP13A2 (PARK9) mutations are related to Kufor-Rakeb syndrome (KRS). We performed genetic analysis of the Ala746Thr variant in an independent cohort of the patients with PD and healthy controls from mainland China. The Ala746Thr variant was present in 1/532 (0.19%) of PD compared with 1/480 (0.21%) of healthy controls (odds ratio = 0.90, 95% CI 0.06, 14.39, P = 1.00). The two subjects carried the heterozygous genotype. Subset analysis in the group = 50 years of age revealed a prevalence of 0.7% in PD compared with 0% in healthy controls and in the group > 50 years of age showed 0% in PD versus 0.3% in healthy controls. We did not observe a significant association between Ala746Thr and Parkinson's disease in Han Chinese population, even after stratification by age at onset. The results suggested that Ala746Thr variant was not a major susceptible factor for PD in Han Chinese people. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 63

页数：3

共 25 条

[1]

ALDIN ASN, 1994, ACTA NEUROL SCAND, V89, P347

[2] Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].