Moving Forward One Notch at a Time

被引:13
作者
Gounder, Mrinal M. [1 ]
Schwartz, Gary K. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
关键词
PHASE-I; INHIBITOR MK-0752; PATHWAY; TRIAL;
D O I
10.1200/JCO.2012.42.3277
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:2291 / 2293
页数:3
相关论文
共 10 条
[1]   Identification of a time- and dose-responsive transcriptional signature of Notch pathway inhibition in plucked human hair follicles following exposure to the gamma-secretase inhibitor MK-0752 [J].
Blackman, Samuel C. ;
Klappenbach, Joel A. ;
Railkar, Radha A. ;
Tanis, Keith ;
Podtelezhnikov, Alexei ;
Loboda, Andrey ;
Dai, Xudong ;
Hing, Jeremy ;
Stone, Julie ;
Harman, Amy ;
Hardwick, James ;
Iannone, Robert ;
Bergstrom, Donald .
MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
[2]   Notch signaling in development and cancer [J].
Bolos, Victoria ;
Grego-Bessa, Joaquin ;
de la Pompa, Jose Luis .
ENDOCRINE REVIEWS, 2007, 28 (03) :339-363
[3]   Notch signalling: a simple pathway becomes complex [J].
Bray, Sarah J. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (09) :678-689
[4]  
Deangelo DJ, 2006, J CLIN ONCOL, V24, p357S
[5]   Phase I Trial of MK-0752 in Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study [J].
Fouladi, Maryam ;
Stewart, Clinton F. ;
Olson, James ;
Wagner, Lars M. ;
Onar-Thomas, Arzu ;
Kocak, Mehmet ;
Packer, Roger J. ;
Goldman, Stewart ;
Gururangan, Sridharan ;
Gajjar, Amar ;
Demuth, Tim ;
Kun, Larry E. ;
Boyett, James M. ;
Gilbertson, Richard J. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (26) :3529-3534
[6]  
Groth C, SEMIN CELL DEV BIOL
[7]   Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors [J].
Krop, Ian ;
Demuth, Tim ;
Guthrie, Tina ;
Wen, Patrick Y. ;
Mason, Warren P. ;
Chinnaiyan, Prakash ;
Butowski, Nicholas ;
Groves, Morris D. ;
Kesari, Santosh ;
Freedman, Steven J. ;
Blackman, Samuel ;
Watters, James ;
Loboda, Andrey ;
Podtelezhnikov, Alexei ;
Lunceford, Jared ;
Chen, Cong ;
Giannotti, Maxine ;
Hing, Jeremy ;
Beckman, Robert ;
LoRusso, Patricia .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (19) :2307-2313
[8]   The role of the PTEN/AKT pathway in NOTCH1-induced leukemia [J].
Palomero, Teresa ;
Dominguez, Maria ;
Ferrando, Adolfo A. .
CELL CYCLE, 2008, 7 (08) :965-970
[9]   Targeting cancer stem cells by inhibiting Wnt, notch, and Hedgehog pathways [J].
Takebe, Naoko ;
Harris, Pamela J. ;
Warren, Ronald Q. ;
Ivy, S. Percy .
NATURE REVIEWS CLINICAL ONCOLOGY, 2011, 8 (02) :97-106
[10]   Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors [J].
Tolcher, Anthony W. ;
Messersmith, Wells A. ;
Mikulski, Stanislaw M. ;
Papadopoulos, Kyriakos P. ;
Kwak, Eunice L. ;
Gibbon, Darlene G. ;
Patnaik, Amita ;
Falchook, Gerald S. ;
Dasari, Arvind ;
Shapiro, Geoffrey I. ;
Boylan, John F. ;
Xu, Zhi-Xin ;
Wang, Ka ;
Koehler, Astrid ;
Song, James ;
Middleton, Steven A. ;
Deutsch, Jonathan ;
DeMario, Mark ;
Kurzrock, Razelle ;
Wheler, Jennifer J. .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (19) :2348-2353