One-pot multicomponent synthesis of indol-3-yl-hydrazinyl thiazoles as antimicrobial agents

被引：22

作者：

Mahmoodi, Nosrat O. ^{[1
]}

Khalili, Behzad ^{[1
]}

Rezaeianzade, Olia ^{[1
]}

Ghavidast, Atefeh ^{[1
]}

机构：

[1] Univ Guilan, Dept Organ Chem, Fac Sci, POB 41335-1914, Rasht, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 08期

关键词：

Bisindole; Thiazole; Bisthiazole; Vilsmeier reaction; Antimicrobial; FACILE REGIOSELECTIVE SYNTHESIS; IN-VITRO; DERIVATIVES; ANTIBACTERIAL; ANALOGS; DESIGN; INHIBITORS; SERIES; DNA;

D O I：

10.1007/s11164-016-2478-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel mono-and bis(indol-3-yl)hydrazinyl thiazole derivatives were efficiently synthesized via one-pot cyclocondensation of mono-or bis(indole-3-carbaldehyde), thiosemicarbazide, and phenacyl bromides. The structure of the products was confirmed by Fourier-transform infrared (FT-IR), H-1 nuclear magnetic resonance (NMR), and C-13 NMR spectra. All synthesized compounds were evaluated for in vitro antibacterial activity against Gram-positive (Bacillus subtilis and Micrococcus luteus) and Gram-negative bacteria (Pseudomonas aeruginosa and Salmonella enteritis). Among the compounds screened, a few were found to be highly effective antibacterial agents. The bis-compounds with OCH3 donating group exhibited good activity against the Gram-positive bacteria.

引用

页码：6531 / 6542

页数：12

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