Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review

被引：7
作者：
Yang, Che-Hsueh [1 ]
Ou, Yen-Chuan [1 ]
Lin, Chi-Chien [2 ]
Lin, Yi-Sheng [1 ]
Tung, Min-Che [1 ]
Yu, Chia-Cheng [3 ]
Lin, Jen-Tai [3 ]
Wen, Chen-Yueh [3 ]
机构：
[1] Tungs Taichung MetroHarbor Hosp, Dept Surg, Div Urol, Taichung 435, Taiwan
[2] Natl Chung Hsing Univ, iEGG & Anim Biotechnol Ctr, Inst Biomed Sci, Taichung 402, Taiwan
[3] Kaohsiung Vet Gen Hosp, Dept Surg, Div Urol, Kaohsiung 813, Taiwan
来源：
LIFE-BASEL | 2022年 / 12卷 / 07期
关键词：
phloretin; pharmacology; therapeutic use; prostatic neoplasms; drug therapy; prostatic hyperplasia; male; NF-KAPPA-B; PROLIFERATIVE INFLAMMATORY ATROPHY; EPITHELIAL-MESENCHYMAL TRANSITION; ANDROGEN RECEPTOR EXPRESSION; ERECTILE DYSFUNCTION; DEPRIVATION THERAPY; CELL-PROLIFERATION; GENE AMPLIFICATION; 2ND-LINE THERAPY; CPG ISLAND;
D O I：
10.3390/life12071029
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Currently, medication for benign prostate hyperplasia (BPH) and prostate cancer (PCa) are mainly based on modulating the hormone and nervous systems. However, side effects often affect patients, and might decrease their commitment to continuing the medication and lower their quality of life. Some studies have indicated that chronic inflammation might be the cause of BPH and PCa. Based on this hypothesis, the effect of phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, has been researched since 2010. Results from animal and in-vitro studies, obtained from databases, also indicate that the use of phloretin in treating BPH and PCa is promising. Due to its effect on inflammatory cytokines, apoptosis or anti-apoptosis, reactive oxygen species, anti-oxidant enzymes and oxidative stress, phloretin is worthy of further study in human clinical trials regarding safety and effective dosages.
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页数：15
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