Pregnancy after lung and heart-lung transplantation: a French multicentre retrospective study of 39 pregnancies

被引:17
作者
Bry, Charlotte [1 ]
Hubert, Dominique [2 ]
Reynaud-Gaubert, Martine [3 ]
Dromer, Claire [4 ]
Mal, Herve [5 ]
Roux, Antoine [6 ]
Boussaud, Veronique [7 ]
Claustre, Johanna [8 ]
Le Pavec, Jerome [9 ]
Murris-Espin, Muriel [10 ]
Danner-Boucher, Isabelle [1 ]
机构
[1] CHU Nantes, Serv Pneumol, Nantes, France
[2] Hop Cochin, Serv Pneumol, Paris, France
[3] CHU Nord, Equipe Transplantat Pulm, Ctr Ressource & Competences Mucoviscidose Adulte, Marseille, France
[4] CHU Bordeaux, Serv Pneumol, Bordeaux, France
[5] Hop Bichat Claude Bernard, Serv Pneumol, Paris, France
[6] Hop Foch, Serv Pneumol, Suresnes, France
[7] Hop Europeen Georges Pompidou, Serv Pneumol, Paris, France
[8] Clin Univ Pneumol Pole Thorax & Vaisseaux, CHU Grenoble, Grenoble, France
[9] Ctr Chirurg Marie Lannelongue, Serv Chirurg Thorac & Vasc, Le Plessis Robinson, France
[10] CHU Toulouse, Serv Pneumol Allergol, CRCM Adulte, Toulouse, France
关键词
INTERNATIONAL SOCIETY; ADULT LUNG; RECIPIENTS; REGISTRY;
D O I
10.1183/23120541.00254-2018
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Pregnancy after lung and heart-lung transplantation remains rare. This French study deals with change in lung function after a pregnancy and the maternal and newborn outcomes. We retrospectively included 39 pregnancies in 35 women aged >20 years. Data on patients, course of pregnancies and newborns were collected from nine transplantation centres. Mean age at time of pregnancy was 28 years. Cystic fibrosis affected 71% of patients. Mean +/- SD time between transplantation and pregnancy was 63 +/- 44 months. 26 births occurred (67%) with a mean term of 36 weeks of amenorrhoea and a mean birthweight of 2409 g. Prematurity was observed in 11 cases (43%). Forced expiratory volume in 1 s was 83.9% of predicted before pregnancy and 77.3% of predicted 1 year after the end of pregnancy (p=0.04). 10 patients developed chronic lung allograft dysfunction after delivery. Nine patients died at a mean +/- SD time after transplantation of 8.2 +/- 7 years and a mean +/- SD time after pregnancy of 4.6 +/- 6.5 years. These data show that pregnancy remains feasible in lung and heart-lung transplant recipients, with more frequent maternal and newborn complications than in the general population. Survival in this cohort appears to be similar to the global survival observed in lung transplant recipients. Planned pregnancy and multidisciplinary follow-up are crucial.
引用
收藏
页数:8
相关论文
共 27 条
[1]  
Armenti Vincent T, 2008, Transplant Rev (Orlando), V22, P223, DOI 10.1016/j.trre.2008.05.001
[2]   Pregnancy and heart-lung transplantation [J].
Baron, O ;
Hubaut, JJ ;
Galetta, D ;
Treilhaud, M ;
Horeau, D ;
Despins, P ;
Michaud, JL ;
Haloun, A .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2002, 21 (08) :914-917
[3]  
Coscia Lisa A, 2010, Clin Transpl, P65
[4]  
Deshpande Neha A, 2013, Rev Obstet Gynecol, V6, P116
[5]  
EBPG Expert Group on Renal Transplantation, 2002, Nephrol Dial Transplant, V17 Suppl 4, P50
[6]   Pregnancy in heart- and heart/lung recipients can be problematic [J].
Estensen, Mette ;
Gude, Einar ;
Ekmehag, Bjorn ;
Lommi, Jyri ;
Bjortuft, Oystein ;
Mortensen, Svend ;
Nystrom, Ulla M. ;
Simonsen, Svein .
SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2011, 45 (06) :349-353
[7]   Three-year results of an investigator-driven multicenter, international, randomized open-label de novo trial to prevent BOS after lung transplantation [J].
Glanville, Allan R. ;
Aboyoun, Christina ;
Klepetko, Walter ;
Reichenspurner, Hermann ;
Treede, Hendrik ;
Verschuuren, Erik A. ;
Boehler, Annette ;
Benden, Christian ;
Hopkins, Peter ;
Corris, Paul. A. .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2015, 34 (01) :16-25
[8]   Mycophenolate Fetal Toxicity and Risk Evaluation and Mitigation Strategies [J].
Kim, M. ;
Rostas, S. ;
Gabardi, S. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (06) :1383-1389
[9]  
KOPITO LE, 1973, FERTIL STERIL, V24, P512
[10]   Pregnancy outcomes in the current era of cystic fibrosis care: A 15-year experience [J].
Lau, Edmund M. T. ;
Barnes, David J. ;
Moriarty, Carmel ;
Ogle, Robert ;
Dentice, Ruth ;
Civitico, Jane ;
Avedello, Aurora ;
Torzillo, Paul J. ;
Bye, Peter T. .
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2011, 51 (03) :220-224