Evaluation of the Mean Corpuscular Volume of Peripheral Blood Mononuclear Cells of HIV Patients by a Coulter Counter To Determine Intracellular Drug Concentrations

被引：70
作者：
Simiele, Marco [1 ]
D'Avolio, Antonio [1 ]
Baietto, Lorena [1 ]
Siccardi, Marco [1 ]
Sciandra, Mauro [1 ]
Agati, Silvia [1 ]
Cusato, Jessica [1 ]
Bonora, Stefano [1 ]
Di Perri, Giovanni [1 ]
机构：
[1] Univ Turin, Dept Infect Dis, Amedeo di Savoia Hosp, Lab Clin Pharmacol & Pharmacogenet, I-10149 Turin, Italy
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 06期
关键词：
TANDEM MASS-SPECTROMETRY; PROTEASE INHIBITORS; INFECTED PATIENTS; PHARMACOKINETICS; LYMPHOCYTES; EXPRESSION; EFAVIRENZ; RITONAVIR; STRATEGY;
D O I：
10.1128/AAC.01236-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mean corpuscular volume (MCV) of peripheral blood mononuclear cells (PBMCs) was determined by Coulter Counter, and data were used to calculate the intracellular drug concentrations. A total of 574 PBMC samples were collected from 190 patients. The MCV was 282.9 fl (minimum, 207.0; maximum, 354.6), with a standard deviation of 8.8%. Previous reports have often used a fixed value of 400 fl for the MCV, which may result in artificially low estimates of the intracellular concentrations of antivirals.
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收藏
页码：2976 / 2978
页数：3
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