HPMC Capsules: Current Status and Future Prospects

被引:107
作者
Al-Tabakha, Moawia M. [1 ]
机构
[1] Al Ain Univ Sci & Technol, Coll Pharm, Al Ain, U Arab Emirates
关键词
HARD GELATIN CAPSULES; SOLID DOSAGE FORMS; IN-VITRO; HYDROXYPROPYL METHYLCELLULOSE; HYPROMELLOSE CAPSULES; ESOPHAGEAL TRANSIT; COATED CAPSULES; DRUG-DELIVERY; FILL WEIGHT; ORAL-CAVITY;
D O I
10.18433/J3K881
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hydroxypropyl methylcellulose (HPMC) is employed for a wide variety of pharmaceutical and food preparations. Its applications as viscolizing agent (thickening agent), coating polymer, bioadhesive, in solid dispersion to enhance solubility, binder in the process of granulation and in modified release formulations have been well documented. One other notable use is in the production of capsule shells, replacing the animal derived gelatin in conventional two-piece capsules. The aim of this review is to systemically survey published literature on the HPMC use in capsule shells and resolve questions regarding their suitability as a replacement for hard gelatin capsules. Future refinements in the production and filling of HPMC capsule shells and improvement in their in vivo/in vitro dissolution would ensure their superiority over hard gelatin capsules.
引用
收藏
页码:428 / 442
页数:15
相关论文
共 68 条
[1]   Effect of glycine citric acid on the dissolution stability of hard gelatin capsules [J].
Adesunloye, TA ;
Stach, PE .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1998, 24 (06) :493-500
[2]   Pharmacokinetics of meloxicam administered as regular and fast dissolving formulations to the rat: Influence of gastrointestinal dysfunction on the relative bioavailability of two formulations [J].
Aghazadeh-Habashi, Ali ;
Jamali, Fakhreddin .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2008, 70 (03) :889-894
[3]  
Akram M, 2010, PAK J PHARM SCI, V23, P149
[4]  
Al-Tabakha M.M, 2007, SAUDI PHARM J, V15, P127
[5]  
ALTABAKHA MM, 2006, J MED J, V40, P250
[6]  
AUGSBURGER LL, 2002, MODERN PHARM, V121
[7]   Bioadhesive dosage forms for esophageal drug delivery [J].
Batchelor, H .
PHARMACEUTICAL RESEARCH, 2005, 22 (02) :175-181
[8]  
Birchall JC, 2008, DRUG DEV IND PHARM, V34, P870, DOI [10.1080/03639040801928903, 10.1080/03639040801928903 ]
[9]   Safety assessment of hydroxypropyl methylcellulose as a food ingredient [J].
Burdock, George A. .
FOOD AND CHEMICAL TOXICOLOGY, 2007, 45 (12) :2341-2351
[10]  
Cade D., 2003, U.S. Patent, Patent No. [US6,517,865B2, 6517865]