Slow-Release Formulation of a New Biological Pesticide, Pyoluteorin, with Mesoporous Silica

被引：78
作者：
Chen, Jie [1 ,2 ]
Wang, Wei [1 ,2 ]
Xu, Yuquan [1 ,2 ]
Zhang, Xuehong [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Microbial Metab, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 01期
关键词：
Slow release; biological pesticide; pyoluteorin; mesoporous silica; LIQUID-CRYSTAL TEMPLATES; DRUG-DELIVERY RATE; PORE-SIZE; MCM-41; IBUPROFEN; SURFACE; ADSORPTION; MONOLITHS; PROPERTY; CHITOSAN;
D O I：
10.1021/jf103640t
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
A slow-release formula of potential biological pesticide Pyoluteorin (Pit) was prepared by using nanophase material of silicon dioxide loading drugs. The final experimental formula was m(Plt: Brij56:TMOS:HCl(aq)) = 0.04:1.4:2:1, synthesized by a highly ordered monolith (HOM) method. This formula can continuously release 85.13 +/- 2.03 % of Pit within 28 days. A characterization study showed the formula formed a well-ordered mesoporous structure, with a surface area of 822 m(2) g(-1), with a measured mesoporous volume of 0.41 cm(3) g(-1) and a narrow distribution for the pore size centered at 2.4 nm. A bioactivity experiment showed it authentically prolonged the antifungal effects. This study is the first to report mesoporous formulations for biological pesticides and indicates a potentially interesting drug carrier. The association of a nanostructured silica to the molecular state of the drug holds great interests for field applications as it overcomes the rapid loss of biological function during drug utilities.
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收藏
页码：307 / 311
页数：5
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