Metabolic signatures of cancer cells and stem cells

被引：234

作者：

Intlekofer, Andrew M. ^{[1
]}

Finley, Lydia W. S. ^{[2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Cell Biol Program, 1275 York Ave, New York, NY 10021 USA

来源：

NATURE METABOLISM | 2019年 / 1卷 / 02期

关键词：

HISTONE DEACETYLASE SIRT6; HYPOXIA-INDUCIBLE FACTORS; ACUTE MYELOID-LEUKEMIA; AMINO-ACID-METABOLISM; ACETYL-COA; ALPHA-KETOGLUTARATE; OXIDATIVE-PHOSPHORYLATION; DNA METHYLATION; ENERGY-METABOLISM; SELF-RENEWAL;

D O I：

10.1038/s42255-019-0032-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In contrast to terminally differentiated cells, cancer cells and stem cells retain the ability to re-enter the cell cycle and proliferate. To proliferate, cells must increase their uptake and catabolism of nutrients to support anabolic cell growth. Intermediates of central metabolic pathways have emerged as key players that influence cell-differentiation 'decisions', processes relevant to both oncogenesis and normal development. Consequently, how cells rewire metabolic pathways to support proliferation can have profound consequences for cellular identity. Here, we discuss the metabolic programs that support proliferation, and we explore how metabolic states are intimately entwined with the cell-fate decisions that characterize stem cells and cancer cells. By comparing the metabolism of pluripotent stem cells and cancer cells, we hope to illuminate common metabolic strategies as well as distinct metabolic features that may represent specialized adaptations to unique cellular demands.

引用

页码：177 / 188

页数：12

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