Changes in breathomics from a 1-year randomized smoking cessation trial of electronic cigarettes

被引:50
作者
Campagna, Davide [1 ,2 ]
Cibella, Fabio [3 ]
Caponnetto, Pasquale [1 ,2 ]
Amaradio, Maria Domenica [2 ]
Caruso, Massimo [2 ]
Morjaria, Jaymin B. [4 ]
Malerba, Mario [5 ,6 ]
Polosa, Riccardo [1 ,2 ]
机构
[1] Univ Catania, Azienda Osped Univ Policlin V Emanuele, Ctr Prevenz & Cura Tabagismo, Via S Sofia 78, I-95123 Catania, Italy
[2] Univ Catania, Azienda Osped Univ Policlin Vittorio Ema Nuele, Dipartimento Med Clin & Sperimentale, Via S Sofia 78, I-95123 Catania, Italy
[3] Natl Res Council Italy, Inst Biomed & Mol Immunol, Via Ugo La Malfa 153, I-0146 Palermo, Italy
[4] Univ Hull, Hull York Med Sch, Castle Hill Hosp, Dept Acad Resp Med, Castle Rd, Cottingham HU16 5JQ, England
[5] Univ Brescia, Dept Internal Med, Piazzale Spedali Civili 1, I-25121 Brescia, Italy
[6] AOU Spedali Civili, Piazzale Spedali Civili 1, I-25121 Brescia, Italy
关键词
eCO; electronic cigarette; FeNo; harm reversal; smoking cessation; tobacco harm reduction; EXHALED NITRIC-OXIDE; CARBON-MONOXIDE; NICOTINE; SMOKERS; AIR; ASTHMATICS; BENEFITS; DISEASE; IMPACT; QUIT;
D O I
10.1111/eci.12651
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Electronic cigarette (EC) use is an emerging behaviour that has been shown to help smokers to reduce cigarette consumption. The aim of this study was to illustrate long-term changes in exhaled breath measurements and respiratory symptoms in smokers invited to quit or reduce their cigarette consumption by switching to ECs. Materials and methods Prospective evaluation of cigarette consumption, fractional nitric oxide concentration in exhaled breath (FeNO), exhaled carbon monoxide (eCO) and symptom scores was performed in a 1-year randomized, controlled trial of 'healthy' smokers receiving 2.4% nicotine, 1.8% nicotine or no nicotine ECs. FeNO and eCO data are presented on the basis of participants' pooled continuous smoking phenotype classification (failures, reducers and quitters). Results A significant effect of quitting classification was found on FeNo and eCO at all time points (P < 0.0001). Among quitters, FeNO (medians and interquartile range) rose from 5.5 (4.5-6.9) ppb to 17.7 (13.3-18.9) ppb by week 52. Baseline eCO (medians and interquartile range) decreased from 17 (12-20) ppm to 3 (1-4) ppm by week 52. No significant changes in FeNO and eCO levels were observed in failures and reducers. Improvements in FeNO and eCO levels were correlated with attenuations in symptom scores. Conclusions Smokers invited to switch to electronic cigarettes who completely abstained from smoking showed steady progressive improvements in their exhaled breath measurements and symptom scores. FeNo and eCO normalization is highly supportive of improved respiratory health outcomes and adds to the notion that quitting from tobacco smoking can reverse harm in the lung.
引用
收藏
页码:698 / 706
页数:9
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