Monitoring Healthy Metabolic Trajectories with Nutritional Metabonomics

被引：8
作者：
Collino, Sebastiano [1 ]
Martin, Francois-Pierre J. [1 ]
Kochhar, Sunil [1 ]
Rezzi, Serge [1 ]
机构：
[1] Nestle Res Ctr, CH-1000 Lausanne 26, Switzerland
来源：
NUTRIENTS | 2009年 / 1卷 / 01期
关键词：
GC (Gas Chromatography); gut microbiota; MS (Mass Spectrometry); metabolomics; metabonomics; metabotypes; NMR (Nuclear Magnetic Resonance) Spectroscopy; nutrimetabonomics; personalized nutrition; UPLC (Ultra Performance Liquid Chromatography); GUT MICROBIOTA; TOXICITY; NMR; DISEASE; PLASMA; MODEL; COMPLICATIONS; MICROFLORA; PHENOTYPES; PROBIOTICS;
D O I：
10.3390/nu1010101
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Metabonomics is a well established analytical approach for the analysis of physiological regulatory processes via the metabolic profiling of biofluids and tissues in living organisms. Its potential is fully exploited in the field of "nutrimetabonomics" that aims at assessing the metabolic effects of active ingredients and foods in individuals. Yet, one of the greatest challenges in nutrition research is to decipher the critical interactions between mammalian organisms and environmental factors, including the gut microbiota. "Nutrimetabonomics" is today foreseen as a powerful approach for future nutritional programs tailored at health maintenance and disease prevention.
引用
收藏
页码：101 / 110
页数：10
相关论文
共 44 条
[1]   NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches [J].
Beckonert, O ;
Bollard, ME ;
Ebbels, TMD ;
Keun, HC ;
Antti, H ;
Holmes, E ;
Lindon, JC ;
Nicholson, JK .
ANALYTICA CHIMICA ACTA, 2003, 490 (1-2) :3-15
[2]   Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins [J].
Beckwith-Hall, BM ;
Nicholson, JK ;
Nicholls, AW ;
Foxall, PJD ;
Lindon, JC ;
Connor, SC ;
Abdi, M ;
Connelly, J ;
Holmes, E .
CHEMICAL RESEARCH IN TOXICOLOGY, 1998, 11 (04) :260-272
[3]   A metabonomic investigation of hepatotoxicity using diffusion-edited 1H NMR spectroscopy of blood serum [J].
Beckwith-Hall, BM ;
Thompson, NA ;
Nicholson, JK ;
Lindon, JC ;
Holmes, E .
ANALYST, 2003, 128 (07) :814-818
[4]   Molecular analysis of the bacterial microbiota in the human stomach [J].
Bik, EM ;
Eckburg, PB ;
Gill, SR ;
Nelson, KE ;
Purdom, EA ;
Francois, F ;
Perez-Perez, G ;
Blaser, MJ ;
Relman, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (03) :732-737
[5]   Allergy development and the intestinal microflora during the first year of life [J].
Björkstén, B ;
Sepp, E ;
Julge, K ;
Voor, T ;
Mikelsaar, M .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (04) :516-520
[6]   Investigation of Human Blood Plasma Sample Preparation for Performing Metabolomics Using Ultrahigh Performance Liquid Chromatography/Mass Spectrometry [J].
Bruce, Stephen J. ;
Tavazzi, Isabelle ;
Parisod, Veronique ;
Rezzi, Serge ;
Kochhar, Sunil ;
Guy, Philippe A. .
ANALYTICAL CHEMISTRY, 2009, 81 (09) :3285-3296
[7]   Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse [J].
Coen, M ;
Ruepp, SU ;
Lindon, JC ;
Nicholson, JK ;
Pognan, F ;
Lenz, EM ;
Wilson, ID .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2004, 35 (01) :93-105
[8]   An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy [J].
Coen, M ;
Lenz, EM ;
Nicholson, JK ;
Wilson, ID ;
Pognan, F ;
Lindon, JC .
CHEMICAL RESEARCH IN TOXICOLOGY, 2003, 16 (03) :295-303
[9]  
Collins MD, 1999, AM J CLIN NUTR, V69, p1052S, DOI 10.1093/ajcn/69.5.1052s
[10]   An ecological and evolutionary perspective on human-microbe mutualism and disease [J].
Dethlefsen, Les ;
McFall-Ngai, Margaret ;
Relman, David A. .
NATURE, 2007, 449 (7164) :811-818
12345