P2O5 Promoted One-Pot Synthesis of 3-aminoimidazo[1,2-a]pyridines under Solvent-Free Conditions

被引：2
作者：
Soleimani, Ebrahim [1 ]
Taran, Mojtaba [2 ]
Zainali, Mohsen [1 ]
Lotfi, Shahram [3 ]
机构：
[1] Razi Univ, Dept Chem, Kermanshah 67149, Iran
[2] Razi Univ, Dept Biol, Kermanshah 6714967346, Iran
[3] Payame Noor Univ, Dept Chem, Tehran, Iran
来源：
LETTERS IN ORGANIC CHEMISTRY | 2012年 / 9卷 / 03期
基金：
美国国家科学基金会;
关键词：
Imidazo[1,2-a]pyridine; P2O5; 2-Aminopyridine; Isocyanide; 3-COMPONENT CONDENSATION; FUSED; 3-AMINOIMIDAZOLES; ANNULATED PYRIDINES; PYRAZINES; PYRIMIDINES;
D O I：
10.2174/157017812800167411
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile, efficient and environment-friendly protocol for the synthesis of 3-aminoimidazo[1,2-a]pyridines has been developed by one-pot condensation of 2-aminopyridine, aromatic aldehyde and alkyl or aryl isocyanide in the presence of P2O5 as catalyst under solvent-free conditions at room temperature. The present approach offers the advantages of clean reaction, simple methodology, short reaction time, high yield, easy purification, and economic availability of the catalyst.
引用
收藏
页码：198 / 201
页数：4
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