Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

被引：13

作者：

Baxa, Jan ^{[1
]}

Hromadka, Milan ^{[2
]}

Sedivy, Jakub ^{[2
]}

Stepankova, Lucie ^{[3
]}

Molacek, Jiri ^{[4
]}

Schmidt, Bernhard ^{[5
]}

Flohr, Thomas ^{[5
]}

Ferda, Jiri ^{[1
]}

机构：

[1] Univ Hosp Plzen, Dept Imaging Methods, Plzen 30460, Czech Republic

[2] Univ Hosp Plzen, Dept Cardiol, Plzen 30460, Czech Republic

[3] Univ Hosp Plzen, Dept Internal Med, Plzen 30460, Czech Republic

[4] Univ Hosp Plzen, Dept Surg, Plzen 30460, Czech Republic

[5] CT Phys & Applicat Dev, Siemens Healthcare, D-91301 Forchheim, Germany

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

COMPUTED-TOMOGRAPHY ANGIOGRAPHY; MAGNETIC-RESONANCE; CARDIAC RISK; BLOOD-FLOW; ADENOSINE; MULTICENTER;

D O I：

10.1155/2015/105629

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stressCT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (>= 50%) determinationwas evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p = 0.002; per-vessel: specificity 95 versus 75%, p = 0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40-70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.

引用

页数：7

共 28 条

[1] Accuracy of Dynamic Computed Tomography Adenosine Stress Myocardial Perfusion Imaging in Estimating Myocardial Blood Flow at Various Degrees of Coronary Artery Stenosis Using a Porcine Animal Model [J].

Bamberg, Fabian ;

Hinkel, Rabea ;

Schwarz, Florian ;

Sandner, Torleif A. ;

Baloch, Elisabeth ;

Marcus, Roy ;

Becker, Alexander ;

Kupatt, Christian ;

Wintersperger, Bernd J. ;

Johnson, Thorsten R. ;

Theisen, Daniel ;

Klotz, Ernst ;

Reiser, Maximilian F. ;

Nikolaou, Konstantin .

INVESTIGATIVE RADIOLOGY, 2012, 47 (01) :71-77

[2] New developments in the preoperative evaluation and perioperative management of coronary artery disease in patients undergoing vascular surgery [J].

Bauer, Stephen M. ;

Cayne, Neal S. ;

Veith, Frank J. .

JOURNAL OF VASCULAR SURGERY, 2010, 51 (01) :242-251

[3] CT imaging of myocardial perfusion: Possibilities and perspectives [J].

Becker, Alexander ;

Becker, Christoph .

JOURNAL OF NUCLEAR CARDIOLOGY, 2013, 20 (02) :289-296

[4] Direct Comparison of Cardiac Magnetic Resonance and Multidetector Computed Tomography Stress-Rest Perfusion Imaging for Detection of Coronary Artery Disease [J].

Bettencourt, Nuno ;

Chiribiri, Amedeo ;

Schuster, Andreas ;

Ferreira, Nuno ;

Sampaio, Francisco ;

Pires-Morais, Gustavo ;

Santos, Lino ;

Melica, Bruno ;

Rodrigues, Alberto ;

Braga, Pedro ;

Azevedo, Luis ;

Teixeira, Madalena ;

Leite-Moreira, Adelino ;

Silva-Cardoso, Jose ;

Nagel, Eike ;

Gama, Vasco .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (10) :1099-1107

[5] Regadenoson-stress myocardial CT perfusion and single-photon emission CT: Rationale, design, and acquisition methods of a prospective, multicenter, multivendor comparison [J].

Cury, Ricardo C. ;

Kitt, Therese M. ;

Feaheny, Kathleen ;

Akin, Jamie ;

George, Richard T. .

JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 2014, 8 (01) :2-12

[6] Adenosine Stress High-Pitch 128-Slice Dual-Source Myocardial Computed Tomography Perfusion for Imaging of Reversible Myocardial Ischemia Comparison With Magnetic Resonance Imaging [J].

Feuchtner, Gudrun ;

Goetti, Robert ;

Plass, Andre ;

Wieser, Monika ;

Scheffel, Hans ;

Wyss, Christophe ;

Stolzmann, Paul ;

Donati, Olivio ;

Schnabl, Johannes ;

Falk, Volkmar ;

Alkadhi, Hatem ;

Leschka, Sebastian ;

Cury, Ricardo C. .

CIRCULATION-CARDIOVASCULAR IMAGING, 2011, 4 (05) :540-549

[7] SIMULTANEOUS ASSESSMENT OF MYOCARDIAL PERFUSION AND LEFT-VENTRICULAR FUNCTION DURING TRANSIENT CORONARY-OCCLUSION [J].

GALLIK, DM ;

OBERMUELLER, SD ;

SWARNA, US ;

GUIDRY, GW ;

MAHMARIAN, JJ ;

VERANI, MS .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 25 (07) :1529-1538

[8] CT stress perfusion imaging for detection of haemodynamically relevant coronary stenosis as defined by FFR [J].

Greif, Martin ;

von Ziegler, Franz ;

Bamberg, Fabian ;

Tittus, Janine ;

Schwarz, Florian ;

D'Anastasi, Melvin ;

Marcus, Roy P. ;

Schenzle, Jan ;

Becker, Christoph ;

Nikolaou, Konstantin ;

Becker, Alexander .

HEART, 2013, 99 (14) :1004-1011

[9] Prognostic value of coronary computed tomography angiography during 5 years of follow-up in patients with suspected coronary artery disease [J].

Hadamitzky, Martin ;

Taeubert, Sebastian ;

Deseive, Simon ;

Byrne, Robert A. ;

Martinoff, Stefan ;

Schoemig, Albert ;

Hausleiter, Joerg .

EUROPEAN HEART JOURNAL, 2013, 34 (42) :3277-3285

[10] Myocardium: Dynamic versus Single-Shot CT Perfusion Imaging [J].

Huber, Armin M. ;

Leber, Vivian ;

Gramer, Bettina M. ;

Muenzel, Daniela ;

Leber, Alexander ;

Rieber, Johannes ;

Schmidt, Martin ;

Vembar, Mani ;

Hoffmann, Ellen ;

Rummeny, Ernst .

RADIOLOGY, 2013, 269 (02) :377-385

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