Anti-inflammatory Triterpenoid Saponins from the Stem Bark of Kalopanax pictus

被引：35
作者：
Quang, Tran H. [1 ,2 ]
Ngan, Nguyen T. T. [1 ]
Minh, Chau V. [2 ]
Kiem, Phan V. [2 ]
Nhiem, Nguyen X. [1 ,2 ]
Tai, Bui H. [1 ]
Thao, Nguyen P. [1 ,2 ]
Tung, Nguyen H. [2 ]
Song, Seok B. [1 ]
Kim, Young H. [1 ]
机构：
[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea
[2] VAST, Inst Marine Biochem, Hanoi, Vietnam
来源：
JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
LEAVES; CONSTITUENTS; GLYCOSIDES; CELLS; GENE;
D O I：
10.1021/np200382s
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new compounds, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (1), 4,23,29-trihydroxy-3,4-seco-olean-12-en-3-oate-28-oic acid (2), 3 beta,6 beta,23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranoside (3), 3-O-[2,3-di-O-acetyl-alpha-L-arabinopyranosyl]hederagenin 28-O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranoside (4), and 3-O-[3,4-di-O-acetyl-alpha-L-arabinopyranosyl]hederagenin 28-O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranoside (5), as well as 10 known compounds (6-15), were isolated from the stem bark of Kalopanax pictus. Compounds 1-5 and 7-14 inhibited TNF alpha-induced NF-kappa B transcriptional activity in HepG2 cells in a dose-dependent manner, with IC(50) values ranging from 0.6 to 16.4 mu M. Furthermore, the transcriptional inhibitory function of these compounds was confirmed on the basis of decreases in COX-2 and iNOS gene expression in HepG2 cells. The structure activity relationship of the compounds with respect to anti-inflammatory activity is also discussed.
引用
收藏
页码：1908 / 1915
页数：8
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