Molecular alterations in meningiomas: Literature review

被引:21
作者
Araujo Pereira, Benedito Jamilson [1 ]
Oba-Shinjo, Sueli Mieko [1 ]
de Almeida, Antonio Nogueira [2 ]
Nagahashi Marie, Suely Kazue [1 ]
机构
[1] Univ Sao Paulo, Fac Med, Lab Mol & Cellular Biol, Dept Neurol,LIM15, Sao Paulo, SP, Brazil
[2] Univ Sao Paulo, Hosp Clin, Div Neurocirurgia Func IPQ, Sao Paulo, SP, Brazil
关键词
Meningioma; Molecular; Mutation; Genetics; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; TERT PROMOTER MUTATIONS; HUMAN BRAIN; MALIGNANT MENINGIOMAS; TUMOR-SUPPRESSOR; INTRACRANIAL MENINGIOMAS; SMARCB1; MUTATIONS; UP-REGULATION; HISTONE H3;
D O I
10.1016/j.clineuro.2018.12.004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system neoplasms. According to the 2016 WHO classification of central nervous system tumors meningiomas are classified into three grades: I, II, and III. Past studies have shown that the risk of meningiomas recurrence is strongly correlated with the molecular profile of the tumor. Extensive whole-exome or whole-genome sequencing has provided a large body of information about the mutational landscape of meningiomas. However, such a stratification of meningiomas based on mutational analysis alone has been proven not to satisfy the clinical need for distinction between patients who need (or do not need) an adjuvant treatment. Combined analysis of exome, transcriptome, methylome and future approaches for epigenetic aspects in meningiomas may allow researchers to unveil a more comprehensive understanding of tumor progression mechanisms and, consequently, a more personalized clinical approach for patients with meningioma. A better understanding of the genetics and clinical behavior of high-grade meningiomas is mandatory in order to better design future clinical trials. By studying the mechanisms underlying these new tumorigenesis pathways, we should be able to offer personalized chemotherapy to patients with surgery and radiation-refractory meningiomas in the near future. The purpose of this article is to accurately bring the compilation of this information, for a greater understanding of the subject.
引用
收藏
页码:89 / 96
页数:8
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