Molecular alterations in meningiomas: Literature review

被引:21
作者
Araujo Pereira, Benedito Jamilson [1 ]
Oba-Shinjo, Sueli Mieko [1 ]
de Almeida, Antonio Nogueira [2 ]
Nagahashi Marie, Suely Kazue [1 ]
机构
[1] Univ Sao Paulo, Fac Med, Lab Mol & Cellular Biol, Dept Neurol,LIM15, Sao Paulo, SP, Brazil
[2] Univ Sao Paulo, Hosp Clin, Div Neurocirurgia Func IPQ, Sao Paulo, SP, Brazil
关键词
Meningioma; Molecular; Mutation; Genetics; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; TERT PROMOTER MUTATIONS; HUMAN BRAIN; MALIGNANT MENINGIOMAS; TUMOR-SUPPRESSOR; INTRACRANIAL MENINGIOMAS; SMARCB1; MUTATIONS; UP-REGULATION; HISTONE H3;
D O I
10.1016/j.clineuro.2018.12.004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system neoplasms. According to the 2016 WHO classification of central nervous system tumors meningiomas are classified into three grades: I, II, and III. Past studies have shown that the risk of meningiomas recurrence is strongly correlated with the molecular profile of the tumor. Extensive whole-exome or whole-genome sequencing has provided a large body of information about the mutational landscape of meningiomas. However, such a stratification of meningiomas based on mutational analysis alone has been proven not to satisfy the clinical need for distinction between patients who need (or do not need) an adjuvant treatment. Combined analysis of exome, transcriptome, methylome and future approaches for epigenetic aspects in meningiomas may allow researchers to unveil a more comprehensive understanding of tumor progression mechanisms and, consequently, a more personalized clinical approach for patients with meningioma. A better understanding of the genetics and clinical behavior of high-grade meningiomas is mandatory in order to better design future clinical trials. By studying the mechanisms underlying these new tumorigenesis pathways, we should be able to offer personalized chemotherapy to patients with surgery and radiation-refractory meningiomas in the near future. The purpose of this article is to accurately bring the compilation of this information, for a greater understanding of the subject.
引用
收藏
页码:89 / 96
页数:8
相关论文
共 132 条
[1]   Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma [J].
Abedalthagafi, Malak ;
Bi, Wenya Linda ;
Aizer, Ayal A. ;
Merrill, Parker H. ;
Brewster, Ryan ;
Agarwalla, Pankaj K. ;
Listewnik, Marc L. ;
Dias-Santagata, Dora ;
Thorner, Aaron R. ;
Van Hummelen, Paul ;
Brastianos, Priscilla K. ;
Reardon, David A. ;
Wen, Patrick Y. ;
Al-Mefty, Ossama ;
Ramkissoon, Shakti H. ;
Folkerth, Rebecca D. ;
Ligon, Keith L. ;
Ligon, Azra H. ;
Alexander, Brian M. ;
Dunn, Ian F. ;
Beroukhim, Rameen ;
Santagata, Sandro .
NEURO-ONCOLOGY, 2016, 18 (05) :649-655
[2]   Increased ratio of vascular endothelial growth factor to semaphorin3A is a negative prognostic factor in human meningiomas [J].
Barresi, Valeria ;
Tuccari, Giovanni .
NEUROPATHOLOGY, 2010, 30 (05) :537-546
[3]   Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion [J].
Bellail, AC ;
Hunter, SB ;
Brat, DJ ;
Tan, C ;
Van Meir, EG .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2004, 36 (06) :1046-1069
[4]   Genomic landscape of intracranial meningiomas [J].
Bi, Wenya Linda ;
Abedalthagafi, Malak ;
Horowitz, Peleg ;
Agarwalla, Pankaj K. ;
Mei, Yu ;
Aizer, Ayal A. ;
Brewster, Ryan ;
Dunn, Gavin P. ;
Al-Mefty, Ossama ;
Alexander, Brian M. ;
Santagata, Sandro ;
Beroukhim, Rameen ;
Dunn, Ian F. .
JOURNAL OF NEUROSURGERY, 2016, 125 (03) :525-535
[5]   A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling [J].
Bianchi, Katiuscia ;
Meier, Pascal .
MOLECULAR CELL, 2009, 36 (05) :736-742
[6]   AKT1E17K in human solid tumours [J].
Bleeker, F. E. ;
Felicioni, L. ;
Buttitta, F. ;
Lamba, S. ;
Cardone, L. ;
Rodolfo, M. ;
Scarpa, A. ;
Leenstra, S. ;
Frattini, M. ;
Barbareschi, M. ;
Del Grammastro, M. ;
Sciarrotta, M. G. ;
Zanon, C. ;
Marchetti, A. ;
Bardelli, A. .
ONCOGENE, 2008, 27 (42) :5648-5650
[7]   CHROMOSOME-TRANSLOCATION T(14-22) AND ONCOGENE (C-SIS) VARIANT IN A PEDIGREE WITH FAMILIAL MENINGIOMA [J].
BOLGER, GB ;
STAMBERG, J ;
KIRSCH, IR ;
HOLLIS, GF ;
SCHWARZ, DF ;
THOMAS, GH .
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (09) :564-567
[8]   Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion [J].
Bourboulia, Dimitra ;
Stetler-Stevenson, William G. .
SEMINARS IN CANCER BIOLOGY, 2010, 20 (03) :161-168
[9]   A physical and functional map of the human TNF-α NF-κB signal transduction pathway [J].
Bouwmeester, T ;
Bauch, A ;
Ruffner, H ;
Angrand, PO ;
Bergamini, G ;
Croughton, K ;
Cruciat, C ;
Eberhard, D ;
Gagneur, J ;
Ghidelli, S ;
Hopf, C ;
Huhse, B ;
Mangano, R ;
Michon, AM ;
Schirle, M ;
Schlegl, J ;
Schwab, M ;
Stein, MA ;
Bauer, A ;
Casari, G ;
Drewes, G ;
Gavin, AC ;
Jackson, DB ;
Joberty, G ;
Neubauer, G ;
Rick, J ;
Kuster, B ;
Superti-Furga, G .
NATURE CELL BIOLOGY, 2004, 6 (02) :97-+
[10]   Alterations in the SMARCB1 (INI1) tumor suppressor gene in familial schwannomatosis [J].
Boyd, C. ;
Smith, M. J. ;
Kluwe, L. ;
Balogh, A. ;
MacCollin, M. ;
Plotkin, S. R. .
CLINICAL GENETICS, 2008, 74 (04) :358-366