Novel insights into cardiomyocytes provided by atomic force microscopy

被引:29
|
作者
Borin, Daniele [1 ]
Pecorari, Ilaria [1 ]
Pena, Brisa [2 ,3 ]
Sbaizero, Orfeo [1 ]
机构
[1] Univ Trieste, Dept Engn & Architecture, Via Valerio 10,Piazzale Europa 1, I-34127 Trieste, Italy
[2] Univ Colorado Denver, Cardiovasc Inst, E 17th Pl, Aurora, CO 80045 USA
[3] Univ Colorado Denver, Bioengn Dept, E 17th Pl, Aurora, CO 80045 USA
关键词
Atomic force microscopy; Cardiomyocyte; Biomechanical properties; Mechanotransduction; Beating activity; CARDIAC MYOCYTES; SINGLE CARDIOMYOCYTES; MECHANICAL-PROPERTIES; INCREASES STIFFNESS; ADHESION; SURFACE; CELLS; CYTOSKELETON; ELASTICITY; MEMBRANE;
D O I
10.1016/j.semcdb.2017.07.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cardiovascular diseases (CVDs) are the number one cause of death globally, therefore interest in studying aetiology, hallmarks, progress and therapies for these disorders is constantly growing. Over the last decades, the introduction and development of atomic force microscopy (AFM) technique allowed the study of biological samples at the micro- and nanoscopic level, hence revealing noteworthy details and paving the way for investigations on physiological and pathological conditions at cellular scale. The present work is aimed to collect and review the literature on cardiomyocytes (CMs) studied by AFM, in order to emphasise the numerous potentialities of this approach and provide a platform for researchers in the field of cardiovascular diseases. Original data are also presented to highlight the application of AFM to characterise the viscoelastic properties of CMs. (c) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4 / 12
页数:9
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