Micafungin Concentrations in the Plasma and Burn Eschar of Severely Burned Patients

被引：16

作者：

Sasaki, Junichi ^{[1
]}

Yamanouchi, Satoshi ^{[2
]}

Kudo, Daisuke ^{[2
]}

Endo, Tomoyuki ^{[2
]}

Nomura, Ryosuke ^{[2
]}

Takuma, Kiyotsugu ^{[1
]}

Kushimoto, Shigeki ^{[2
]}

Shinozawa, Yotaro

Kishino, Satoshi ^{[3
]}

Hori, Shingo ^{[1
]}

Aikawa, Naoki ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Emergency & Crit Care Med, Tokyo, Japan

[2] Tohoku Univ, Grad Sch Med, Div Emergency Med, Sendai, Miyagi 980, Japan

[3] Meiji Pharmaceut Univ, Dept Medicat Use Anal & Clin Res, Tokyo, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 02期

关键词：

FUNGAL-INFECTIONS; PHARMACOKINETICS; DISPOSITION; LIVER; CARE;

D O I：

10.1128/AAC.05381-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC(90)s of micafungin against clinically important Candida and Aspergillus species.

引用

页码：1113 / 1115

页数：3

共 19 条

[1] Clinical effects of micafungin, a novel echinocandin antifungal agent, on systemic fungal infections in surgery, emergency, and intensive-care medicine: evaluation using the AKOTT algorithm [J].