Distal Weak Coordination of Acetamides in Ruthenium(II)-Catalyzed C-H Activation Processes

被引：80

作者：

Bu, Qingqing ^{[1
]}

Rogge, Torben ^{[1
]}

Kotek, Vladislav ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 03期

关键词：

arylacetamides; density functional theory; homogeneous catalysis; mechanisms; ruthenium; LATE-STAGE DIVERSIFICATION; CATALYZED DIRECT ARYLATION; CROSS-COUPLING REACTIONS; BOND ACTIVATION; DIRECTING GROUP; BASIS-SETS; FUNCTIONALIZATION; HYDROARYLATION; ALKENYLATIONS; ARENES;

D O I：

10.1002/anie.201711108

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

C-H activations with challenging arylacetamides were accomplished by versatile ruthenium(II) biscarboxylate catalysis. The distal C-H functionalization offers ample scopeincluding twofold oxidative C-H functionalizations and alkyne hydroarylationsthrough facile base-assisted internal electrophilic-type substitution (BIES) C-H ruthenation by weak O-coordination.

引用

页码：765 / 768

页数：4

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