Fibrous-structured magnetic and mesoporous Fe3O4/silica microspheres: synthesis and intracellular doxorubicin delivery

被引：96

作者：

Gai, Shili ^{[1
]}

Yang, Piaoping ^{[1
]}

Ma, Ping'an ^{[2
]}

Wang, Dong ^{[1
]}

Li, Chunxia ^{[2
]}

Li, Xingbo ^{[1
]}

Niu, Na ^{[1
]}

Lin, Jun ^{[2
]}

机构：

[1] Harbin Engn Univ, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resources Utilizat, Changchun 130022, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2011年 / 21卷 / 41期

基金：

中国国家自然科学基金;

关键词：

IRON-OXIDE NANOPARTICLES; SOL-GEL PROCESS; SILICA NANOSPHERES; CONTROLLED-RELEASE; SPHERES; NANOCRYSTALS; SYSTEM; FE3O4; FUNCTIONALIZATION; LUMINESCENT;

D O I：

10.1039/c1jm13357h

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A novel, fibrous-structured bifunctional (magnetic and mesoporous) Fe3O4/silica microsphere was successfully synthesized through a simple and economical self-assembled process in which hydrophobic 9 nm-Fe3O4 nanocrystals were directly used without modifications. The obtained material is performed as a drug delivery carrier to investigate the in vitro and intracellular delivery properties of doxorubicin hydrochloride (DOX). X-Ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N-2 adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), and superconducting quantum interference device (SQUID) were employed to characterize the composite. The results reveal that the novel composite exhibits typical mesoporous structure, narrow size distribution, good monodispersity, and superparamagnetic features. Notably, confocal laser scanning microscopy (CLSM) images indicate that the DOX-loaded sample could deliver DOX into the nuclei of HeLa cells to kill cells. Also, MTT assay confirms that the DOX-loaded sample leads to pronounced and efficient cytotoxic effects to L929 fibroblast cells, even similar to that of free DOX at high concentrations, whereas the pure material is non-toxic. Therefore, the novel material is expected to have potential application for targeted cancer therapy.

引用

页码：16420 / 16426

页数：7

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