Pro-senescence therapy for cancer treatment

被引：367
作者：
Nardella, Caterina [1 ,2 ]
Clohessy, John G. [1 ]
Alimonti, Andrea [1 ,3 ]
Pandolfi, Pier Paolo [1 ]
机构：
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Pathol & Med,Canc Genet Program, Sch Med,Beth Israel Deaconess Canc Ctr, Boston, MA 02215 USA
[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Preclin Murine Pharmacogenet Facil, Sch Med, Boston, MA 02215 USA
[3] Oncol Inst So Switzerland IOSI, CH-6500 Bellinzona, Switzerland
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 07期
基金：
美国国家卫生研究院;
关键词：
ONCOGENE-INDUCED SENESCENCE; DNA-DAMAGE RESPONSE; CYCLIN-DEPENDENT KINASES; CELLULAR SENESCENCE; TUMOR-SUPPRESSOR; IN-VIVO; TELOMERE DYSFUNCTION; BREAST-CANCER; P53; PATHWAY; HUMAN-CELLS;
D O I：
10.1038/nrc3057
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.
引用
收藏
页码：503 / 511
页数：9
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