Type I Interferons in Autoimmunity

被引：47

作者：

Fernandez-Ruiz, Ruth ^{[1
]}

Niewold, Timothy B. ^{[2
]}

机构：

[1] NYU Grossman Sch Med, Div Rheumatol, Dept Med, New York, NY USA

[2] NYU Grossman Sch Med, Judith & Stewart Colton Ctr Autoimmun, Dept Med Res, 550 1St Ave, New York, NY 10016 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2022年 / 142卷 / 3 PT B期

基金：

美国国家卫生研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; PLASMACYTOID DENDRITIC CELLS; GENOME-WIDE ASSOCIATION; INDUCIBLE GENE-EXPRESSION; DISTINCT BIOLOGICAL-ACTIVITIES; DISEASE RISK VARIANT; NAIVE CD4+T CELLS; IFN-ALPHA; FUNCTIONAL POLYMORPHISM; RHEUMATOID-ARTHRITIS;

D O I：

10.1016/j.jid.2021.11.031

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies targeting IFN-1 pathways. In this review, we provide an overview of the signaling pathway and immune functions of IFN-1s in health and disease. We also review the systemic autoimmune diseases classically associated with IFN-1 upregulation and current therapeutic strategies targeting the IFN-1 system.

引用

页码：793 / 803

页数：11

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