Type I Interferons in Autoimmunity

被引：35
作者：
Fernandez-Ruiz, Ruth [1 ]
Niewold, Timothy B. [2 ]
机构：
[1] NYU Grossman Sch Med, Div Rheumatol, Dept Med, New York, NY USA
[2] NYU Grossman Sch Med, Judith & Stewart Colton Ctr Autoimmun, Dept Med Res, 550 1St Ave, New York, NY 10016 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2022年 / 142卷 / 3 PT B期
基金：
美国国家卫生研究院;
关键词：
SYSTEMIC-LUPUS-ERYTHEMATOSUS; PLASMACYTOID DENDRITIC CELLS; GENOME-WIDE ASSOCIATION; INDUCIBLE GENE-EXPRESSION; DISTINCT BIOLOGICAL-ACTIVITIES; DISEASE RISK VARIANT; NAIVE CD4+T CELLS; IFN-ALPHA; FUNCTIONAL POLYMORPHISM; RHEUMATOID-ARTHRITIS;
D O I：
10.1016/j.jid.2021.11.031
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies targeting IFN-1 pathways. In this review, we provide an overview of the signaling pathway and immune functions of IFN-1s in health and disease. We also review the systemic autoimmune diseases classically associated with IFN-1 upregulation and current therapeutic strategies targeting the IFN-1 system.
引用
收藏
页码：793 / 803
页数：11
相关论文
共 166 条
  • [11] Environmental exposures and the development of systemic lupus erythematosus
    Barbhaiya, Medha
    Costenbader, Karen H.
    [J]. CURRENT OPINION IN RHEUMATOLOGY, 2016, 28 (05) : 497 - 505
  • [12] Systemic sclerosis after interferon-alfa therapy for myeloproliferative disorders
    Beretta, L
    Caronni, M
    Vanoli, M
    Scorza, R
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2002, 147 (02) : 385 - 386
  • [13] Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort
    Bianchi, Matteo
    Kozyrev, Sergey V.
    Notarnicola, Antonella
    Hultin Rosenberg, Lina
    Karlsson, Asa
    Pucholt, Pascal
    Rothwell, Simon
    Alexsson, Andrei
    Sandling, Johanna K.
    Andersson, Helena
    Cooper, Robert G.
    Padyukov, Leonid
    Tjarnlund, Anna
    Dastmalchi, Maryam
    Meadows, Jennifer R. S.
    Pyndt Diederichsen, Louise
    Molberg, Oyvind
    Chinoy, Hector
    Lamb, Janine
    Ronnblom, Lars
    Lindblad-Toh, Kerstin
    Lundberg, Ingrid E.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2022, 74 (02) : 342 - 352
  • [14] Interleukin-6 and Type I Interferon-Regulated Genes and Chemokines Mark Disease Activity in Dermatomyositis
    Bilgic, Hatice
    Ytterberg, Steven R.
    Amin, Shreyasee
    McNallan, Kelly T.
    Wilson, Joseph C.
    Koeuth, Thearith
    Ellingson, Sonja
    Newman, Brant
    Bauer, Jason W.
    Peterson, Erik J.
    Baechler, Emily C.
    Reed, Ann M.
    [J]. ARTHRITIS AND RHEUMATISM, 2009, 60 (11): : 3436 - 3446
  • [15] The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity
    Billi, Allison C.
    Gharaee-Kermani, Mehrnaz
    Fullmer, Joseph
    Tsoi, Lam C.
    Hill, Brett D.
    Gruszka, Dennis
    Ludwig, Jessica
    Xing, Xianying
    Estadt, Shannon
    Wolf, Sonya J.
    Rizvi, Syed Monem
    Berthier, Celine C.
    Hodgin, Jeffrey B.
    Reamer, Maria A.
    Sarkar, Mrinal K.
    Liang, Yun
    Uppala, Ranjitha
    Shao, Shuai
    Zeng, Chang
    Harms, Paul W.
    Verhaegen, Monique E.
    Voorhees, John J.
    Wen, Fei
    Ward, Nicole L.
    Dlugosz, Andrzej A.
    Kahlenberg, J. Michelle
    Gudjonsson, Johann E.
    [J]. JCI INSIGHT, 2019, 4 (08)
  • [16] Environmental factors in the pathogenesis of primary Sjogren's syndrome
    Bjork, A.
    Mofors, J.
    Wahren-Herlenius, M.
    [J]. JOURNAL OF INTERNAL MEDICINE, 2020, 287 (05) : 475 - 492
  • [17] The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis
    Brkic, Zana
    van Bon, Lenny
    Cossu, Marta
    van Helden-Meeuwsen, Cornelia G.
    Vonk, Madelon C.
    Knaapen, Hanneke
    van den Berg, Wim
    Dalm, Virgil A.
    Van Daele, Paul L.
    Severino, Adriana
    Maria, Naomi I.
    Guillen, Samara
    Dik, Willem A.
    Beretta, Lorenzo
    Versnel, Marjan A.
    Radstake, Timothy
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (08) : 1567 - 1573
  • [18] MDA5+ D Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript
    Cassius, Charle
    Amode, Reyhan
    Delord, Marc
    Battistella, Maxime
    Poirot, Justine
    How-Kit, Alexandre
    Lepelletier, Clemence
    Jachiet, Marie
    de Masson, Adele
    Frumholtz, Laure
    Cordoliani, Florence
    Boccara, David
    Lehmann-Che, Jacqueline
    Wong, Jennifer
    Dubanchet, Sylvie
    Alberdi, Antonio Jose
    Merandet, Marine
    Bagot, Martine
    Bensussan, Armand
    Bouaziz, Jean-David
    Le Buanec, Helene
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2020, 140 (06) : 1276 - 1279
  • [19] Genetic Association Study of TNFAIP3, IFIH1, IRF5 Polymorphisms with Polymyositis/Dermatomyositis in Chinese Han Population
    Chen, Si
    Wang, Qian
    Wu, Ziyan
    Li, Yuan
    Li, Ping
    Sun, Fei
    Zheng, Wenjie
    Wu, Qingjun
    Wu, Chanyuan
    Deng, Chuiwen
    Zhang, Fengchun
    Li, Yongzhe
    [J]. PLOS ONE, 2014, 9 (10):
  • [20] Genome-Wide DNA Methylation Profiles Reveal Common Epigenetic Patterns of Interferon-Related Genes in Multiple Autoimmune Diseases
    Chen, Sidi
    Pu, Weilin
    Guo, Shicheng
    Jin, Li
    He, Dongyi
    Wang, Jiucun
    [J]. FRONTIERS IN GENETICS, 2019, 10
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