Countering the classical renin-angiotensin system

被引：1

作者：

Noto, Natalia M. ^{[1
]}

Restrepo, Yazmin M. ^{[1
]}

Speth, Robert C. ^{[1
]}

机构：

[1] Nova Southeastern Univ, Coll Pharm, Ft Lauderdale, FL 33328 USA

来源：

CLINICAL SCIENCE | 2021年 / 135卷 / 23期

关键词：

BLOOD-PRESSURE; ACE2; OVEREXPRESSION; HYPERTENSION; EXPRESSION; PEPTIDE;

D O I：

10.1042/CS20211043

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It is well-established that Ang-(1-7) counteracts the effects of Ang II in the periphery, while stimulating vasopressin release and mimicking the activity of Ang II in the brain, through interactions with various receptors. The rapid metabolic inactivation of Ang-(1-7) has proven to be a limitation to therapeutic administration of the peptide. To circumvent this problem, Alves et al. (Clinical Science (2021) 135(18), https://doi.org/10.1042/CS20210599) developed a new transgenic rat model that overexpresses an Ang-(1-7)-producing fusion protein. In this commentary, we discuss potential concerns with this model while also highlighting advances that can ensue from this significant technical feat.

引用

页码：2619 / 2623

页数：5

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