Methyl-blocked dimeric α,γ-peptide nanotube segments:: Formation of a peptide heterodimer through backbone-backbone interactions

被引：72

作者：

Brea, RJ ^{[1
]}

Amorín, M ^{[1
]}

Castedo, L ^{[1
]}

Granja, JR ^{[1
]}

机构：

[1] Univ Santiago, Fac Quim, Dept Quim Organ & Unidade Asociada, CSIC, Santiago De Compostela 15782, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 35期

关键词：

amino acids; dimerization; nanotubes; peptides; self-assembly;

D O I：

10.1002/anie.200501555

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclic peptides can dimerize through β-sheet-like hydrogen bonding. Heterodimerization is favored over homodimerization, which creates interesting combinatorial possibilities without detriment to the functionalization of amino acid side chains. These dimers represent a new class of self-assembling peptide nanotubes in which the hydrophobicity of the internal cavity (see picture) can be controlled. (Graph Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5710 / 5713

页数：4

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