Quality of life score as a prognosticator for pharyngeal cancer patients treated with radiotherapy

被引：4

作者：

Ishiyama, Hiromichi ^{[1
]}

Kawakami, Shogo ^{[1
]}

Sekiguchi, Akane ^{[1
]}

Kainuma, Takuro ^{[1
]}

Miyamoto, Shunsuke ^{[2
]}

Yamashita, Taku ^{[2
]}

Nakano, Masahiro ^{[1
]}

机构：

[1] Kitasato Univ, Dept Radiat Oncol, Sch Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa, Japan

[2] Kitasato Univ, Dept Otorhinolaryngol & Head & Neck Surg, Sch Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa, Japan

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

PHASE-3; RANDOMIZED-TRIAL; RADIATION PLUS CISPLATIN; LOCALLY ADVANCED HEAD; NECK-CANCER; LONG-TERM; SURVIVAL PREDICTOR; PERFORMANCE STATUS; CARCINOMA; INDICATORS; DYSPHAGIA;

D O I：

10.1038/s41598-022-06441-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The purpose of this study was to evaluate the prognostic value of quality of life (QOL) scores acquired not only pre-treatment, but also 1 month after treatment for locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) in patients with pharyngeal cancer treated using radiotherapy. Data for 102 patients with naso-, oro-, or hypo-pharyngeal cancer treated between December 2008 and September 2017 were retrospectively analyzed. About 90% of the patients were male. The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) was used for QOL assessments. Associations between QLQ-C30 scores before and 1 month after treatment and outcomes including LRC, DMFS, and OS were analyzed using Cox proportional hazard models. Median follow-up was 37 months (range, 5-117 months). Three-year LRC, DMFS, and OS rates were 77.8%, 60.0%, and 66.5%, respectively. Pre-treatment emotional functioning and diarrhea at 1 month after treatment were identified as significant predictors of LRC. Pre-treatment global QOL and diarrhea at 1 month after treatment were detected as significant predictors of DMFS. Pre-treatment emotional functioning, pre-treatment appetite loss, and diarrhea at 1 month after treatment were detected as significant predictors of OS. Diarrhea at 1 month after treatment was the most powerful QOL variable for predicting LRC, DMFS and OS. Our study revealed that several QOL scores not only before treatment but also 1 month after treatment correlated with LRC, DMFS and OS. In particular, the diarrhea domain of QOL at 1 month after treatment offered the most powerful prognosticator for pharyngeal cancer patients treated with radiotherapy.

引用

页数：8