Reduced thymocyte development in sonic hedgehog knockout embryos

被引：75
作者：
Shah, DK [1 ]
Hager-Theodorides, AL [1 ]
Outram, SV [1 ]
Ross, SE [1 ]
Varas, A [1 ]
Crompton, T [1 ]
机构：
[1] Univ London Imperial Coll Sci & Technol, Dept Biol Sci, London SW7 2AZ, England
来源：
JOURNAL OF IMMUNOLOGY | 2004年 / 172卷 / 04期
基金：
英国惠康基金;
关键词：
D O I：
10.4049/jimmunol.172.4.2296
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells.
引用
收藏
页码：2296 / 2306
页数：11
相关论文
共 37 条
[1]   Lymphoid precursors [J].
Akashi, K ;
Reya, T ;
Dalma-Weiszhausz, D ;
Weissman, IL .
CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (02) :144-150
[2]   The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal [J].
Alcedo, J ;
Ayzenzon, M ;
VonOhlen, T ;
Noll, M ;
Hooper, JE .
CELL, 1996, 86 (02) :221-232
[3]   Cellular interactions in thymocyte development [J].
Anderson, G ;
Moore, NC ;
Owen, JJT ;
Jenkinson, EJ .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :73-99
[4]  
ASAMOTO H, 1981, LAB INVEST, V45, P418
[5]   Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation [J].
Bhardwaj, G ;
Murdoch, B ;
Wu, D ;
Baker, DP ;
Williams, KP ;
Chadwick, K ;
Ling, LE ;
Karanu, FN ;
Bhatia, M .
NATURE IMMUNOLOGY, 2001, 2 (02) :172-180
[6]   Specification of neuronal fates in the ventral neural tube [J].
Briscoe, J ;
Ericson, J .
CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (01) :43-49
[7]   DEFECTIVE LYMPHOID DEVELOPMENT IN MICE LACKING EXPRESSION OF THE COMMON CYTOKINE RECEPTOR-GAMMA CHAIN [J].
CAO, XQ ;
SHORES, EW ;
HULI, J ;
ANVER, MR ;
KELSALL, BL ;
RUSSELL, SM ;
DRAGO, J ;
NOGUCHI, M ;
GRINBERG, A ;
BLOOM, ET ;
PAUL, WE ;
KATZ, SI ;
LOVE, PE ;
LEONARD, WJ .
IMMUNITY, 1995, 2 (03) :223-238
[8]   A positive look at double-negative thymocytes [J].
Ceredig, R ;
Rolink, T .
NATURE REVIEWS IMMUNOLOGY, 2002, 2 (11) :888-896
[9]  
Chen Y, 1998, DEVELOPMENT, V125, P4943
[10]   Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function [J].
Chiang, C ;
Ying, LTT ;
Lee, E ;
Young, KE ;
Corden, JL ;
Westphal, H ;
Beachy, PA .
NATURE, 1996, 383 (6599) :407-413
1234