Reduced thymocyte development in sonic hedgehog knockout embryos

被引：75
作者：
Shah, DK [1 ]
Hager-Theodorides, AL [1 ]
Outram, SV [1 ]
Ross, SE [1 ]
Varas, A [1 ]
Crompton, T [1 ]
机构：
[1] Univ London Imperial Coll Sci & Technol, Dept Biol Sci, London SW7 2AZ, England
来源：
JOURNAL OF IMMUNOLOGY | 2004年 / 172卷 / 04期
基金：
英国惠康基金;
关键词：
D O I：
10.4049/jimmunol.172.4.2296
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells.
引用
收藏
页码：2296 / 2306
页数：11
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