Free-Radical Triggered Ordered Domino Reaction: An Approach to C-C Bond Formation via Selective Functionalization of α-Hydroxyl-(sp3)C-H in Fluorinated Alcohols

被引：53

作者：

Xu, Zhengbao ^{[1
]}

Hang, Zhaojia ^{[1
]}

Liu, Zhong-Quan ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 18期

基金：

美国国家科学基金会;

关键词：

N-SULFONYL ALDIMINES; H BOND; CASCADE REACTIONS; CARBOXYLIC-ACIDS; NITROGEN-HETEROCYCLES; CATALYZED METHYLATION; ACTIVATED ALKENES; GRIGNARD-REAGENTS; COUPLING REACTION; ALLYLIC ALCOHOLS;

D O I：

10.1021/acs.orglett.6b01946

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A free-radical mediated highly ordered radical addition/cydization/(sp(3))C-C(sp(3)) formation domino reaction is developed. Three new C-C bonds are formed one by one in a mixed system. Furthermore, it represents the first example of cascade C-C bond formation via selective functionalization of alpha(-)hydroxyl-C(sp(3))-H in fluorinated alcohols.

引用

页码：4470 / 4473

页数：4