Free-Radical Triggered Ordered Domino Reaction: An Approach to C-C Bond Formation via Selective Functionalization of α-Hydroxyl-(sp3)C-H in Fluorinated Alcohols

被引：53
|
作者：
Xu, Zhengbao [1 ]
Hang, Zhaojia [1 ]
Liu, Zhong-Quan [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 18期
基金：
美国国家科学基金会;
关键词：
N-SULFONYL ALDIMINES; H BOND; CASCADE REACTIONS; CARBOXYLIC-ACIDS; NITROGEN-HETEROCYCLES; CATALYZED METHYLATION; ACTIVATED ALKENES; GRIGNARD-REAGENTS; COUPLING REACTION; ALLYLIC ALCOHOLS;
D O I：
10.1021/acs.orglett.6b01946
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A free-radical mediated highly ordered radical addition/cydization/(sp(3))C-C(sp(3)) formation domino reaction is developed. Three new C-C bonds are formed one by one in a mixed system. Furthermore, it represents the first example of cascade C-C bond formation via selective functionalization of alpha(-)hydroxyl-C(sp(3))-H in fluorinated alcohols.
引用
收藏
页码：4470 / 4473
页数：4
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