Clinical Manifestations of Hepatic Encephalopathy

被引:14
作者
Dellatore, Peter [1 ,2 ]
Cheung, Maggie [1 ,2 ]
Mahpour, Noah Y. [1 ,2 ]
Tawadros, Augustine [1 ,2 ]
Rustgi, Vinod K. [3 ]
机构
[1] Rutgers Robert Wood Johnson Med Sch, Dept Internal Med, 125 Paterson St, New Brunswick, NJ 08901 USA
[2] Dept Med, 125 Paterson St, New Brunswick, NJ 08901 USA
[3] Rutgers Robert Wood Johnson Med Sch, Dept Gastroenterol & Hepatol, 125 Paterson St,Suite 5100B, New Brunswick, NJ 08901 USA
关键词
Hepatic encephalopathy; Classification; Grading; Clinical manifestations; PREVALENCE; DIAGNOSIS;
D O I
10.1016/j.cld.2020.01.010
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatic encephalopathy (HE) occurs in patients with acute-on-chronic liver disease. It has a wide progression of symptoms, with its initial presentation being subtle. The symptoms of HE mainly affect mental status, the musculoskeletal system, and mood/behavior. Its severity ranges from minor disturbances in sleep-wake cycle to the patient being comatose. HE is categorized based on 4 main features: the underlying disease, the severity of manifestations, the time course, and whether precipitating factors are present. The severity of the manifestations is classically identified using the West Haven Criteria. There are several other clinical tests, but they require further validation.
引用
收藏
页码:189 / +
页数:9
相关论文
共 25 条
[1]  
Amer Assoc Study Liver Dis, 2014, J HEPATOL, V61, P642, DOI 10.1016/j.jhep.2014.05.042
[2]   Characteristics of minimal hepatic encephalopathy [J].
Amodio, P ;
Montagnese, S ;
Gatta, A ;
Morgan, MY .
METABOLIC BRAIN DISEASE, 2004, 19 (3-4) :253-267
[3]   Spectrum of Neurocognitive Impairment in Cirrhosis: Implications for the Assessment of Hepatic Encephalopathy [J].
Bajaj, Jasmohan S. ;
Wade, James B. ;
Sanyal, Arun J. .
HEPATOLOGY, 2009, 50 (06) :2014-2021
[4]   Clinical and Neurologic Manifestation of Minimal Hepatic Encephalopathy and Overt Hepatic Encephalopathy [J].
Basu, P. Patrick ;
James, Niraj .
CLINICS IN GERIATRIC MEDICINE, 2015, 31 (03) :461-+
[5]   High prevalence of sleep disturbance in cirrhosis [J].
Córdoba, J ;
Cabrera, J ;
Lataif, L ;
Penev, P ;
Zee, P ;
Blei, AT .
HEPATOLOGY, 1998, 27 (02) :339-345
[6]   New assessment of hepatic encephalopathy [J].
Cordoba, Juan .
JOURNAL OF HEPATOLOGY, 2011, 54 (05) :1030-1040
[7]   Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: Final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 [J].
Ferenci, P ;
Lockwood, A ;
Mullen, K ;
Tarter, R ;
Weissenborn, K ;
Blei, AT .
HEPATOLOGY, 2002, 35 (03) :716-721
[8]   Prognosis and 1-year mortality of intensive care unit patients with severe hepatic encephalopathy [J].
Fichet, Jerome ;
Mercier, Emmanuelle ;
Genee, Olivier ;
Garot, Denis ;
Legras, Annick ;
Dequin, Pierre-Francois ;
Perrotin, Dominique .
JOURNAL OF CRITICAL CARE, 2009, 24 (03) :364-370
[9]  
Frederick R Todd, 2011, Gastroenterol Hepatol (N Y), V7, P222
[10]  
García-Martínez R, 2011, DIS MARKERS, V31, P171, DOI [10.1155/2011/832031, 10.3233/DMA-2011-0840]