COMPARATIVE STUDY OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF ACETAMIDIC DERIVATIVES

The antimicrobial activity of the amide derivatives depends on the stability of the complex formed by their interactions with the biological receptor. The interaction between the ligand (amide derivative) and the biological receptor is visualized in the 2D diagrams of the molecular docking method used. In hydrogen-binding interactions are involved the amino acids Gly133, Gly86, Gly156, Gin154, Thr155 from the active sites of Gram-negative Escherichia coli bacteria (PDB ID: 3t88) for the most active compounds. In the case of Gram-positive Staphylococcus aureus bacteria (PDB ID: 3Q8U), the hydrogen bond interactions of the most active compounds involve the amino acids Arg102, Asn112, His115, His52, Thr91. For the Candida albicans (PDB ID: 3WBZ), the hydrogen bonds involve the same amino acids Glu15, Lys14 si Tyr17. In the case of Aspergillus niger fungi (PDB ID: 1QO7), the hydrogen bonds involve the following amino acids Ala217, Arg219, Arg199, Cys216 si Thr317. In all cases, the atoms involved in the interaction are nitrogen and oxygen in the molecules of the two participants.