Resistance and recurrence of malignancies after CAR-T cell therapy

被引：14

作者：

Zeng, Wanying ^{[1
]}

Zhang, Pumin ^{[1
,2
,3
]}

机构：

[1] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & The, Guangxi Key Lab Biotargeting Theranost,Guangxi Ta, Nanning 530021, Guangxi, Peoples R China

[2] Zhejiang Univ, Zhejiang Prov Key Lab Pancreat Dis, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China

[3] Zhejiang Univ, Inst Translat Med, Med Sch, Hangzhou 310058, Zhejiang, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2022年 / 410卷 / 02期

关键词：

CAR-T cell therapy; Resistance; Recurrence; Mechanisms; Treatment strategies; CHIMERIC-ANTIGEN-RECEPTOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; UMBILICAL-CORD BLOOD; MEMORY STEM-CELLS; ADOPTIVE IMMUNOTHERAPY; REGENERATIVE THERAPY; ANTITUMOR IMMUNITY; GENE-THERAPY; PHASE-I; TUMOR;

D O I：

10.1016/j.yexcr.2021.112971

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The emergence of chimeric antigen receptor T (CAR-T) cell therapy has ushered a new era in cancer therapy, especially the treatment of hematological malignancies. However, resistance and recurrence still occur in some patients after CAR-T cell treatment. CAR-T cell inefficiency and tumor escape have emerged as the main chal-lenges for the long-term disease control of B cell malignancies by this promising immunotherapy. In solid tumor treatment, CAR-T cells must also overcome many hurdles from the tumor or immune-suppressed tumor envi-ronment, which have become obstacles to the advancement of CAR-T therapy. Therefore, an understanding of the mechanisms underlying post-CAR treatment failure in patients is necessary. In this review, we characterize some mechanisms of resistance and recurrence after CAR-T cell therapy and correspondingly suggest reasonable treatment strategies.

引用

页数：10

共 137 条

[81] Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma [J].

Neelapu, S. S. ;

Locke, F. L. ;

Bartlett, N. L. ;

Lekakis, L. J. ;

Miklos, D. B. ;

Jacobson, C. A. ;

Braunschweig, I. ;

Oluwole, O. O. ;

Siddiqi, T. ;

Lin, Y. ;

Timmerman, J. M. ;

Stiff, P. J. ;

Friedberg, J. W. ;

Flinn, I. W. ;

Goy, A. ;

Hill, B. T. ;

Smith, M. R. ;

Deol, A. ;

Farooq, U. ;

McSweeney, P. ;

Munoz, J. ;

Avivi, I. ;

Castro, J. E. ;

Westin, J. R. ;

Chavez, J. C. ;

Ghobadi, A. ;

Komanduri, K. V. ;

Levy, R. ;

Jacobsen, E. D. ;

Witzig, T. E. ;

Reagan, P. ;

Bot, A. ;

Rossi, J. ;

Navale, L. ;

Jiang, Y. ;

Aycock, J. ;

Elias, M. ;

Chang, D. ;

Wiezorek, J. ;

Go, W. Y. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (26) :2531-2544

[82] Managing the toxicities of CAR T-cell therapy [J].

Neelapu, Sattva S. .

HEMATOLOGICAL ONCOLOGY, 2019, 37 :48-52

[83] Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice [J].

Nishina, Sohji ;

Yamauchi, Akira ;

Kawaguchi, Takumi ;

Kaku, Kohei ;

Goto, Moritaka ;

Sasaki, Kyo ;

Hara, Yuichi ;

Tomiyama, Yasuyuki ;

Kuribayashi, Futoshi ;

Torimura, Takuji ;

Hino, Keisuke .

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2019, 7 (01) :115-134

[84] Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia [J].

Orlando, Elena J. ;

Han, Xia ;

Tribouley, Catherine ;

Wood, Patricia A. ;

Leary, Rebecca J. ;

Riester, Markus ;

Levine, John E. ;

Qayed, Muna ;

Grupp, Stephan A. ;

Boyer, Michael ;

De Moerloose, Barbara ;

Nemecek, Eneida R. ;

Bittencourt, Henrique ;

Hiramatsu, Hidefumi ;

Buechner, Jochen ;

Davies, Stella M. ;

Verneris, Michael R. ;

Nguyen, Kevin ;

Brogdon, Jennifer L. ;

Bitter, Hans ;

Morrissey, Michael ;

Pierog, Piotr ;

Pantano, Serafino ;

Engelman, Jeffrey A. ;

Winckler, Wendy .

NATURE MEDICINE, 2018, 24 (10) :1504-+

[85] Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment [J].

Ostrand-Rosenberg, Suzanne ;

Fenselau, Catherine .

JOURNAL OF IMMUNOLOGY, 2018, 200 (02) :422-431

[86] High efficacy and safety of low-dose CD19-directed CAR-T cell therapy in 51 refractory or relapsed B acute lymphoblastic leukemia patients [J].

Pan, J. ;

Yang, J. F. ;

Deng, B. P. ;

Zhao, X. J. ;

Zhang, X. ;

Lin, Y. H. ;

Wu, Y. N. ;

Deng, Z. L. ;

Zhang, Y. L. ;

Liu, S. H. ;

Wu, T. ;

Lu, P. H. ;

Lu, D. P. ;

Chang, A. H. ;

Tong, C. R. .

LEUKEMIA, 2017, 31 (12) :2587-2593

[87] Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia [J].

Park, Jae H. ;

Riviere, Isabelle ;

Gonen, Mithat ;

Wang, Xiuyan ;

Senechal, Brigitte ;

Curran, Kevin J. ;

Sauter, Craig ;

Wang, Yongzeng ;

Santomasso, Bianca ;

Mead, Elena ;

Roshal, Mikhail ;

Maslak, Peter ;

Davila, Marco ;

Brentjens, Renier J. ;

Sadelain, Michel .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (05) :449-459

[88] Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies [J].

Parker, Kevin R. ;

Migliorini, Denis ;

Perkey, Eric ;

Yost, Kathryn E. ;

Bhaduri, Aparna ;

Bagga, Puneet ;

Haris, Mohammad ;

Wilson, Neil E. ;

Liu, Fang ;

Gabunia, Khatuna ;

Scholler, John ;

Montine, Thomas J. ;

Bhoj, Vijay G. ;

Reddy, Ravinder ;

Mohan, Suyash ;

Maillard, Ivan ;

Kriegstein, Arnold R. ;

June, Carl H. ;

Chang, Howard Y. ;

Posey, Avery D., Jr. ;

Satpathy, Ansuman T. .

CELL, 2020, 183 (01) :126-+

[89] Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning [J].

Pegram, Hollie J. ;

Lee, James C. ;

Hayman, Erik G. ;

Imperato, Gavin H. ;

Tedder, Thomas F. ;

Sadelain, Michel ;

Brentjens, Renier J. .

BLOOD, 2012, 119 (18) :4133-4141

[90] γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma [J].

Pont, Margot J. ;

Hill, Tyler ;

Cole, Gabriel O. ;

Abbott, Joe J. ;

Kelliher, Jessica ;

Salter, Alexander I. ;

Hudecek, Michael ;

Comstock, Melissa L. ;

Rajan, Anusha ;

Patel, Bharvin K. R. ;

Voutsinas, Jenna M. ;

Wu, Qian ;

Liu, Lingfeng ;

Cowan, Andrew J. ;

Wood, Brent L. ;

Green, Damian J. ;

Riddell, Stanley R. .

BLOOD, 2019, 134 (19) :1585-1597

← 4 5 6 7 8 9 10 11 12 13 →