Resistance and recurrence of malignancies after CAR-T cell therapy

被引：13

作者：

Zeng, Wanying ^{[1
]}

Zhang, Pumin ^{[1
,2
,3
]}

机构：

[1] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & The, Guangxi Key Lab Biotargeting Theranost,Guangxi Ta, Nanning 530021, Guangxi, Peoples R China

[2] Zhejiang Univ, Zhejiang Prov Key Lab Pancreat Dis, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China

[3] Zhejiang Univ, Inst Translat Med, Med Sch, Hangzhou 310058, Zhejiang, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2022年 / 410卷 / 02期

关键词：

CAR-T cell therapy; Resistance; Recurrence; Mechanisms; Treatment strategies; CHIMERIC-ANTIGEN-RECEPTOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; UMBILICAL-CORD BLOOD; MEMORY STEM-CELLS; ADOPTIVE IMMUNOTHERAPY; REGENERATIVE THERAPY; ANTITUMOR IMMUNITY; GENE-THERAPY; PHASE-I; TUMOR;

D O I：

10.1016/j.yexcr.2021.112971

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The emergence of chimeric antigen receptor T (CAR-T) cell therapy has ushered a new era in cancer therapy, especially the treatment of hematological malignancies. However, resistance and recurrence still occur in some patients after CAR-T cell treatment. CAR-T cell inefficiency and tumor escape have emerged as the main chal-lenges for the long-term disease control of B cell malignancies by this promising immunotherapy. In solid tumor treatment, CAR-T cells must also overcome many hurdles from the tumor or immune-suppressed tumor envi-ronment, which have become obstacles to the advancement of CAR-T therapy. Therefore, an understanding of the mechanisms underlying post-CAR treatment failure in patients is necessary. In this review, we characterize some mechanisms of resistance and recurrence after CAR-T cell therapy and correspondingly suggest reasonable treatment strategies.

引用

页数：10

共 137 条

[91] Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia [J].

Porter, David L. ;

Hwang, Wei-Ting ;

Frey, Noelle V. ;

Lacey, Simon F. ;

Shaw, Pamela A. ;

Loren, Alison W. ;

Bagg, Adam ;

Marcucci, Katherine T. ;

Shen, Angela ;

Gonzalez, Vanessa ;

Ambrose, David ;

Grupp, Stephan A. ;

Chew, Anne ;

Zheng, Zhaohui ;

Milone, Michael C. ;

Levine, Bruce L. ;

Melenhorst, Jan J. ;

June, Carl H. .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (303)

[92] Intra-tumor heterogeneity from a cancer stem cell perspective [J].

Prasetyanti, Pramudita R. ;

Medema, Jan Paul .

MOLECULAR CANCER, 2017, 16

[93] Preclinical Development of Bivalent Chimeric Antigen Receptors Targeting Both CD19 and CD22 [J].

Qin, Haiying ;

Ramakrishna, Sneha ;

Nguyen, Sang ;

Fountaine, Thomas J. ;

Ponduri, Anusha ;

Stetler-Stevenson, Maryalice ;

Yuan, Constance M. ;

Haso, Waleed ;

Shern, Jack F. ;

Shah, Nirali N. ;

Fry, Terry J. .

MOLECULAR THERAPY-ONCOLYTICS, 2018, 11 :127-137

[94] CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies [J].

Qin, Hong ;

Dong, Zhenyuan ;

Wang, Xiuli ;

Cheng, Wesley A. ;

Wen, Feng ;

Xue, Weili ;

Sun, Han ;

Walter, Miriam ;

Wei, Guowei ;

Smith, D. Lynne ;

Sun, Xiuhua ;

Fei, Fan ;

Xie, Jianming ;

Panagopoulou, Theano I. ;

Chen, Chun-Wei ;

Song, Joo Y. ;

Aldoss, Ibrahim ;

Kayembe, Clarisse ;

Sarno, Luisa ;

Muschen, Markus ;

Inghirami, Giorgio G. ;

Forman, Stephen J. ;

Kwak, Larry W. .

SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (511)

[95] Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade [J].

Qin, Ye ;

Vasilatos, Shauna N. ;

Chen, Lin ;

Wu, Hao ;

Cao, Zhishen ;

Fu, Yumei ;

Huang, Min ;

Vlad, Anda M. ;

Lu, Binfeng ;

Oesterreich, Steffi ;

Davidson, Nancy E. ;

Huang, Yi .

ONCOGENE, 2019, 38 (03) :390-405

[96]

Qiu S., 2021, GENETIC MECH LEUKEMI

[97] Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma [J].

Raje, Noopur ;

Berdeja, Jesus ;

Lin, Yi ;

Siegel, David ;

Jagannath, Sundar ;

Madduri, Deepu ;

Liedtke, Michaela ;

Rosenblatt, Jacalyn ;

Maus, Marcela V. ;

Turka, Ashley ;

Lam, Lyh-Ping ;

Morgan, Richard A. ;

Friedman, Kevin ;

Massaro, Monica ;

Wang, Julie ;

Russotti, Greg ;

Yang, Zhihong ;

Campbell, Timothy ;

Hege, Kristen ;

Petrocca, Fabio ;

Quigley, M. Travis ;

Munshi, Nikhil ;

Kochenderfer, James N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (18) :1726-1737

[98] A versatile system for rapid multiplex genome-edited CAR T cell generation [J].

Ren, Jiangtao ;

Zhang, Xuhua ;

Liu, Xiaojun ;

Fang, Chongyun ;

Jiang, Shuguang ;

June, Carl H. ;

Zhao, Yangbing .

ONCOTARGET, 2017, 8 (10) :17002-17011

[99] Cell-Based Therapy Using Umbilical Cord Blood for Novel Indications in Regenerative Therapy and Immune Modulation: An Updated Systematic Scoping Review of the Literature [J].

Rizk, Mina ;

Aziz, Joseph ;

Shorr, Risa ;

Allan, David S. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (10) :1607-1613

[100] Heterogeneity of surface CD19 and CD22 expression in B lymphoblastic leukemia [J].

Rosenthal, Jaclyn ;

Naqvi, Ammar S. ;

Luo, Minjie ;

Wertheim, Gerald ;

Paessler, Michele ;

Thomas-Tikhonenko, Andrei ;

Rheingold, Susan R. ;

Pillai, Vinodh .

AMERICAN JOURNAL OF HEMATOLOGY, 2018, 93 (11) :E352-E355

← 5 6 7 8 9 10 11 12 13 14 →