EPIGENETIC ALTERATIONS OF TUMOR MARKER MICRORNAs: TOWARDS NEW CANCER THERAPIES

被引：5
作者：
Wei, Jia
Xie, Li
Taron, Miguel [2 ]
Rose, Rafael [2 ]
Liu, Baorui [1 ]
机构：
[1] Nanjing Univ, Sch Med, Clin Canc Inst, Dept Oncol,Drum Tower Hosp, Nanjing 210008, Peoples R China
[2] Hosp Badalona Germans Trias & Pujol, Catalan Inst Oncol, Badalona, Spain
来源：
DRUG NEWS & PERSPECTIVES | 2010年 / 23卷 / 10期
关键词：
HUMAN LUNG CANCERS; EXPRESSION PROFILES; DOWN-REGULATION; BREAST-CANCER; PROMOTES TRANSFORMATION; CIRCULATING MICRORNAS; CELL-PROLIFERATION; PREDICTS SURVIVAL; DNA METHYLATION; SUPPRESSOR GENE;
D O I：
10.1358/dnp.2010.23.10.1560143
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
MicroRNAs (miRNAs) are a class of short noncoding RNAs that participate in mastering the balance of gene-regulating networks. By targeting and controlling expression of messenger RNA, miRNAs can control highly complex signal transduction pathways and other biological pathways. Unique aberrant expression of miRNA at each stage of cancer development suggests that miRNA could play a novel role in cancer diagnosis and therapeutic strategies. Accumulated information on epigenetic modification of miRNA suggests a promising platform for miRNA in cancer therapy. Clinical applications exploiting the understanding of miRNA's function will be the next great challenge in cancer research.
引用
收藏
页码：655 / 661
页数：7
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