Upper airway neuromuscular compensation during sleep is defective in obstructive sleep apnea

被引:111
作者
McGinley, Brian M. [1 ]
Schwartz, Alan R. [1 ]
Schneider, Hartmut [1 ]
Kirkness, Jason P. [1 ]
Smith, Philip L. [1 ]
Patil, Susheel P. [1 ]
机构
[1] Johns Hopkins Univ, Div Pulm & Crit Care Med, Johns Hopkins Sleep Disorders Ctr, Baltimore, MD USA
关键词
upper airway neuromuscular control; neuromuscular responses;
D O I
10.1152/japplphysiol.01214.2007
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Obstructive sleep apnea is the result of repeated episodes of upper airway obstruction during sleep. Recent evidence indicates that alterations in upper airway anatomy and disturbances in neuromuscular control both play a role in the pathogenesis of obstructive sleep apnea. We hypothesized that subjects without sleep apnea are more capable of mounting vigorous neuromuscular responses to upper airway obstruction than subjects with sleep apnea. To address this hypothesis we lowered nasal pressure to induce upper airway obstruction to the verge of periodic obstructive hypopneas (cycling threshold). Ten patients with obstructive sleep apnea and nine weight-, age-, and sex-matched controls were studied during sleep. Responses in genioglossal electromyography (EMG(GG)) activity (tonic, peak phasic, and phasic EMGGG), maximal inspiratory airflow (V(I)max), and pharyngeal transmural pressure (P-TM) were assessed during similar degrees of sustained conditions of upper airway obstruction and compared with those obtained at a similar nasal pressure under transient conditions. Control compared with sleep apnea subjects demonstrated greater EMGGG, VImax, and PTM responses at comparable levels of mechanical and ventilatory stimuli at the cycling threshold, during sustained compared with transient periods of upper airway obstruction. Furthermore, the increases in EMGGG activity in control compared with sleep apnea subjects were observed in the tonic but not the phasic component of the EMG response. We conclude that sustained periods of upper airway obstruction induce greater increases in tonic EMGGG, V(I)max, and P-TM in control subjects. Our findings suggest that neuromuscular responses protect individuals without sleep apnea from developing upper airway obstruction during sleep.
引用
收藏
页码:197 / 205
页数:9
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