Type I IFNs in the female reproductive tract: The first line of defense in an ever-changing battleground

被引:17
作者
Cumming, Helen E. [1 ]
Bourke, Nollaig M. [2 ]
机构
[1] Monash Univ, Hudson Inst Med Res, Ctr Innate Immun & Infect Dis, Clayton, Vic, Australia
[2] Trinity Coll Dublin, Trinity Translat Med Inst, Dept Med Gerontol, Dublin, Ireland
关键词
Chlamydia; female reproductive tract; HIV; hormonal regulation; mucosal immunity; Type I IFNs; Zika; UTERINE NK CELLS; GMP-AMP SYNTHASE; ZIKA VIRUS; SEXUAL TRANSMISSION; INTERFERON-ALPHA; EPITHELIAL-CELLS; MENSTRUAL-CYCLE; HIV-INFECTION; INNATE IMMUNITY; RNA;
D O I
10.1002/JLB.MR0318-122RR
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The primary function of the female reproductive tract (FRT) is to enable successful reproduction, yet the biologic mechanisms required to accomplish this, which include fluctuating sex hormones and tolerance of semen and a semi-allogeneic fetus, can leave this unique mucosal environment susceptible to pathogenic challenge. Consequently, the FRT has evolved specialized innate and adaptive immune responses tailored to protecting itself from infection without compromising reproductive success. A family of innate immune cytokines that has emerged as important regulators of these immune responses is the type I IFNs. Type I IFNs are typically rapidly produced in response to pathogenic stimulation and are capable of sculpting pleotropic biologic effects, including immunomodulation, antiproliferative effects, and inducing antiviral and bactericidal molecules. Here, we review what is currently known about type I IFN-mediated immunity in the FRT in human, primate, and murine models and explore their importance with respect to three highly relevant FRT infections: HIV, Zika, and Chlamydia.
引用
收藏
页码:353 / 361
页数:9
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