Magnesium causes nitric oxide independent coronary artery vasodilation in humans

被引:33
|
作者
Teragawa, H [1 ]
Kato, M [1 ]
Yamagata, T [1 ]
Matsuura, H [1 ]
Kajiyama, G [1 ]
机构
[1] Hiroshima Univ, Sch Med, Dept Internal Med 1, Minami Ku, Hiroshima 7348851, Japan
关键词
coronary artery; coronary blood flow; magnesium sulfate; nitric oxide;
D O I
10.1136/heart.86.2.212
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-To determine how magnesium affects human coronary arteries and whether endothelium derived nitric oxide (EDNO) is involved in the coronary arterial response to magnesium. Design-Quantitative coronary angiography and Doppler flow velocity measurements were used to determine the effects of the nitric oxide synthase inhibitor N-G-monomethyl-L-arginine (L-NMMA) on magnesium induced dilation of the epicardial and resistance coronary arteries. Setting-Hiroshima University Hospital a tertiary cardiology centre. Patients-17 patients with angiographically normal coronary arteries. Interventions-Magnesium sulfate (MgSO4) (0.02 mmol/min and 0.2 mmol/min) was infused for two minutes into the left coronary ostium before and after intracoronary infusion of L-NMMA. Main outcome measures-Diameter of the proximal and distal segments of the epicardial coronary arteries and coronary blood flow. Results-At a dose of 0.02 mmol/min, MgSO4 did not affect the coronary arteries. At a dose of 0.2 mmol/min, MgSO4 caused coronary artery dilation (mean (SEM) proximal diameter 3.00 (0-09) to 3.11 (0.09) mm; distal 1.64 (0.06) to 1.77 (0.07) mm) and increased coronary blood flow (79.3 (7.5) to 101.4 (9.9) ml/min, p < 0.001 v baseline for all). MgSO4 increased the changes in these parameters after the infusion of L-N.MMA (p < 0.001 v baseline). Conclusions-Magnesium dilates both the epicardial and resistance coronary arteries in humans. Furthermore, the coronary arterial response to magnesium is dose dependent and independent of EDNO.
引用
收藏
页码:212 / 216
页数:5
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