Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

被引：36

作者：

Chajes, Veronique ^{[1
,5
]}

Jenab, Mazda ^{[1
]}

Romieu, Isabelle ^{[1
]}

Ferrari, Pietro ^{[1
]}

Dahm, Christina C. ^{[2
,3
]}

Overvad, Kim ^{[3
]}

Egeberg, Rikke ^{[4
]}

Tjonneland, Anne

Clavel-Chapelon, Francoise ^{[5
]}

Boutron-Ruault, Marie-Christine ^{[5
]}

Engel, Pierre ^{[5
]}

Teucher, Birgit ^{[6
]}

Kaaks, Rudolf ^{[6
]}

Floegel, Anna ^{[7
]}

Boeing, Heiner ^{[7
]}

Trichopoulou, Antonia

Dilis, Vardis ^{[8
,9
]}

Karapetyan, Tina ^{[9
]}

Mattiello, Amalia ^{[10
]}

Tumino, Rosario ^{[11
,12
]}

Grioni, Sara ^{[13
,30
]}

Palli, Domenico ^{[14
]}

Vineis, Paolo ^{[15
,16
]}

Bueno-de-Mesquita, H. Bas ^{[17
,18
]}

Numans, Mattijs E. ^{[19
]}

Peeters, Petra H. M. ^{[19
]}

Lund, Eiliv ^{[20
]}

Navarro, Carmen ^{[23
,24
]}

Ramon Quiros, Jose ^{[26
]}

Sanchez-Cantalejo, Emilio ^{[24
,27
]}

Barricarte Gurrea, Aurelio ^{[24
,28
]}

Dorronsoro, Miren ^{[24
,29
]}

Regner, Sara

Sonestedt, Emily ^{[31
]}

Wirfaelt, Elisabet ^{[31
]}

Khaw, Kay-Tee ^{[32
]}

Wareham, Nick ^{[33
]}

Allen, Naomi E. ^{[34
]}

Crowe, Francesca L. ^{[34
]}

Rinaldi, Sabina ^{[1
]}

Slimani, Nadia ^{[1
]}

Carneiro, Fatima ^{[21
,22
]}

Riboli, Elio ^{[35
]}

Gonzalez, Carlos A. ^{[25
]}

机构：

[1] Int Agcy Res Canc, F-69372 Lyon 08, France

[2] Aarhus Univ Hosp, Dept Cardiol, Aalborg, Denmark

[3] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[4] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[5] Hop Paul Brousse, Ctr Rech Epidemiol & Sante Populat, UMR 1018, Villejuif, France

[6] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[7] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[8] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[9] Hellen Hlth Fdn, Athens, Greece

[10] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[11] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[12] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[13] IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[14] ISPO, Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[15] Univ Turin, Serv Epidemiol Tumori, Turin, Italy

[16] CPO Piemonte, Turin, Italy

[17] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[18] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[19] Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands

[20] Univ Tromso, Inst Community Med, Tromso, Norway

[21] Univ Porto, Inst Mol Pathol & Immunol, P-4100 Oporto, Portugal

[22] Fac Med Porto, Oporto, Portugal

[23] Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[24] CIBER Epidemiol & Salud Publ, Barcelona, Spain

[25] Catalan Inst Oncol, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[26] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[27] Andalusian Sch Publ Hlth, Granada, Spain

[28] Navarre Publ Hlth Inst, Pamplona, Spain

[29] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[30] Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Surg Clin, Malmo, Sweden

[31] Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden

[32] Univ Cambridge, Scholl Clin Med, Cambridge, England

[33] MRC Epidemiol Unit, Cambridge, England

[34] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[35] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Epidemiol & Publ Hlth, London, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2011年 / 94卷 / 05期

基金：

英国医学研究理事会;

关键词：

HELICOBACTER-PYLORI INFECTION; NUTRIENT INTAKE PATTERNS; BREAST-CANCER; PROSTATE-CANCER; PROSPECTIVE COHORT; COLORECTAL-CANCER; MEAT CONSUMPTION; DIETARY-INTAKE; STOMACH; ASSOCIATION;

D O I：

10.3945/ajcn.110.005892

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). Design: Fatty acids were measured by gas chromatography in pre-diagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks. Results: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-gamma-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), alpha-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to alpha-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66). Conclusion: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, alpha-linolenic acid, and di-homo-gamma-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk. Am J Clin Nutr 2011;94:1304-13.

引用

页码：1304 / 1313

页数：10

共 59 条

[51]

2-3

[52] Correlation Between Serum Phospholipid Fatty Acids and Dietary Intakes Assessed a Few Years Earlier [J].

Thiebaut, Anne C. M. ;

Rotival, Maxime ;

Gauthier, Estelle ;

Lenoir, Gilbert M. ;

Boutron-Ruault, Marie-Christine ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Chajes, Veronique .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2009, 61 (04) :500-509

[53] Dietary intakes of ω-6 and ω-3 polyunsaturated fatty acids and the risk of breast cancer [J].

Thiebaut, Anne C. M. ;

Chajes, Veronique ;

Gerber, Mariette ;

Boutron-Ruault, Marie-Christine ;

Joulin, Virginie ;

Lenoir, Gilbert ;

Berrino, Franco ;

Riboli, Elio ;

Benichou, Jacques ;

Clavel-Chapelon, Francoise .

INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (04) :924-931

[54] Salt, salted food intake, and risk of gastric cancer: Epidemiologic evidence [J].

Tsugane, S .

CANCER SCIENCE, 2005, 96 (01) :1-6

[55] Diet and the risk of gastric cancer: review of epidemiological evidence [J].

Tsugane, Shoichiro ;

Sasazuki, Shizuka .

GASTRIC CANCER, 2007, 10 (02) :75-83

[56] Salt intake, cured meat consumption, refrigerator use and stomach cancer incidence: a prospective cohort study (Netherlands) [J].

van den Brandt, PA ;

Botterweck, AAM ;

Goldbohm, RA .

CANCER CAUSES & CONTROL, 2003, 14 (05) :427-438

[57] trans-Fatty acid consumption and its association with distal colorectal cancer in the North Carolina Colon Cancer Study II [J].

Vinikoor, Lisa C. ;

Millikan, Robert C. ;

Satia, Jessie A. ;

Schroeder, Jane C. ;

Martin, Christopher F. ;

Ibrahim, Joseph G. ;

Sandler, Robert S. .

CANCER CAUSES & CONTROL, 2010, 21 (01) :171-180

[58] Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysis [J].

Wang, WH ;

Huang, JQ ;

Zheng, GF ;

Lam, SK ;

Karlberg, J ;

Wong, BCY .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2003, 95 (23) :1784-1791

[59] Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma [J].

Yahagi, N ;

Shimano, H ;

Hasegawa, K ;

Ohashi, K ;

Matsuzaka, T ;

Najima, Y ;

Sekiya, M ;

Tomita, S ;

Okazaki, H ;

Tamura, Y ;

Iizuka, Y ;

Ohashi, K ;

Nagai, R ;

Ishibashi, S ;

Kadowaki, T ;

Makuuchi, M ;

Ohnishi, S ;

Osuga, J ;

Yamada, N .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (09) :1316-1322

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