The significance of the SDF-1/CXCR4 signaling pathway in the normal development

被引：62
作者：
Sadri, Farzad [1 ]
Rezaei, Zohreh [2 ,3 ]
Fereidouni, Mohammad [3 ,4 ]
机构：
[1] Birjand Univ Med Sci, Student Res Comm, Birjand, Iran
[2] Univ Sistan & Baluchestan, Dept Biol, Zahedan, Iran
[3] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran
[4] Birjand Univ Med Sci, Fac Med, Dept Med Immunol, Birjand, Iran
来源：
MOLECULAR BIOLOGY REPORTS | 2022年 / 49卷 / 04期
关键词：
SDF-1; CXCR4; Chemokines; Stem cells; Migration; CELL-DERIVED FACTOR-1; MESENCHYMAL STEM-CELLS; CHEMOKINE RECEPTOR CXCR4; FACTOR-I; BONE-MARROW; HEMATOPOIETIC STEM; SDF-1-CXCR4; AXIS; PROGENITOR CELLS; REGULATORY ROLE; EXPRESSION;
D O I：
10.1007/s11033-021-07069-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation. Therefore, the current review aimed to summarize the related studies that addressed the molecular signature of the SDF-1/CXCR4 pathway and to explain how this axis is involved in normal events.
引用
收藏
页码：3307 / 3320
页数：14
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