miR-373 Inhibits Glioma Cell U251 Migration and Invasion by Down-Regulating CD44 and TGFBR2

被引：40

作者：

Wei, Furong ^{[1
]}

Wang, Qianrong ^{[2
]}

Su, Qinghong ^{[1
]}

Huang, Haiyan ^{[1
]}

Luan, Junwen ^{[1
]}

Xu, Xiaoqun ^{[1
]}

Wang, Junfu ^{[1
]}

机构：

[1] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Inst Basic Med, 18877 Jingshi Rd, Jinan 250062, Shandong, Peoples R China

[2] Shandong Acad Med Sci, Shandong Canc Hosp, Dept Radiat Oncol, 440 Jiyan Rd, Jinan, Peoples R China

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2016年 / 36卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Glioma; miRNA-373; CD44; TGFBR2; Migration; Invasion; TUMOR INVASION; CANCER; MICRORNAS; PROLIFERATION; PROMOTES; GLIOBLASTOMA; PROGRESSION; EXPRESSION; MIR-520C; THERAPY;

D O I：

10.1007/s10571-016-0338-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glioblastoma multiforme (GBM) is the most malignant glioma, unveiling the underlying mechanisms of its aggressiveness could promote the discovery of potential targets for effective treatment. MicroRNAs (miRNAs) are important participants in both development and disease, its involvement in cancers has long been recognized. In this study, we investigated the role of miRNA-373 (miR-373) in GBM cell line U251, demonstrated that although miR-373 does not affect cell growth of U251, it inhibits migration and invasion of U251. Forced expression of miR-373 down-regulates the expressions CD44 and TGFBR2, while knockdown of CD44 and TGFBR2 presents the similar phenotype as miR-373 overexpression, suggesting that CD44 and TGFBR2 are functional targets of miR-373, down-regulation of CD44 and TGFBR2 by miR-373 are partly responsible for the migration, and invasion suppressive role of miR-373 in U251.

引用

页码：1389 / 1397

页数：9

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