Chemoselective fluorination of 2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones using DAST

被引：9

作者：

Bonacorso, Helio G. ^{[1
]}

Porte, Liliane M. F. ^{[1
]}

Navarini, Jussara ^{[1
]}

Paim, Gisele R. ^{[1
]}

Luz, Fabio M. ^{[1
]}

Oliveira, Lenon M. ^{[1
]}

Whietan, Carson W. ^{[1
]}

Martins, Marcos A. P. ^{[1
]}

Zanatta, Nilo ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, Nucleo Quim Heterociclos NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 26期

关键词：

DIETHYLAMINOSULFUR TRIFLUORIDE; FLUOROORGANIC COMPOUNDS; MEDICINAL CHEMISTRY;

D O I：

10.1016/j.tetlet.2011.04.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, diethylaminosulfur trifluoride (DAST) was successfully applied in monofluorination reactions of some trifluoromethyl substituted 2-hydroxy-2H-chromenones, employing a general, mild, and efficient methodology. The fluorinated compounds (2-fluoro-2H-chromenones) were synthesized as unique products by a chemoselective reaction in 63-81% yield despite the presence of different reactive sites subjected to reactions with DAST. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3333 / 3335

页数：3

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