Role of Radiotherapy in Kaposi's Sarcoma: Review of the Literature

Radiotherapy (RT) is an effective treatment for local palliation of Kaposi's sarcoma. However, there is no standardized RT dose and technique. Usually, electrons or low-energy photons are used, and various bolus materials are utilized for better dose distribution. High treatment response rates have been reported in all RT schemes. When the literature is examined in terms of dose and schema, for cutaneous lesions, single fraction treatments <8 Gy are less effective in terms of complete response (CR), and more effective results were obtained in total doses of 20 Gy and above. A total of 15 Gy for oral lesions, 20 Gy in eyelid conjunctival and scrotal lesions, and 30 Gy for cutaneous lesions are recommended. Planning target volume margins are defined as 2 mm(-5) mm for orthovoltage devices and 0.5-2 cm for other treatments. In this study, we aimed to review the RT studies presented in the literature.