Histiocytic Glomerulopathy Associated With Hemophagocytic Lymphohistiocytosis

被引：3

作者：

Dokouhaki, Pouneh ^{[1
]}

Van der Merwe, Da-elene ^{[2
]}

Vats, Karan ^{[1
]}

Said, Samar M. ^{[3
]}

D'Agati, Vivette D. ^{[4
]}

Nasr, Samih H. ^{[3
]}

机构：

[1] Univ Saskatchewan, Dept Pathol & Lab Med, St Pauls Hosp, 1720 20th St W, Saskatoon, SK S7M 0Z9, Canada

[2] Univ Saskatchewan, Dept Med, Div Nephrol, Saskatoon, SK, Canada

[3] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[4] Columbia Univ, Dept Pathol & Cell Biol, Med Ctr, New York, NY USA

来源：

KIDNEY MEDICINE | 2022年 / 4卷 / 02期

关键词：

KIDNEY INJURY; DIAGNOSIS;

D O I：

10.1016/j.xkme.2021.10.009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Hemophagocytic lymphohistiocytosis (HLH) is a systemic inflammatory syndrome characterized by heightened activation and proliferation of nonmalignant macrophages and excessive cytokine release. Whereas acute kidney injury is common in this syndrome, direct glomerular involvement by activated histiocytes is very rare. We present the case of a man in his 20s who presented with fevers, malaise, flank pain, anemia, thrombocytopenia, severe acute kidney injury, and proteinuria. A kidney biopsy revealed histiocytic glomerulopathy and subacute thrombotic microangiopathy, and he was diagnosed with HLH. Recovery of kidney function occurred following steroid therapy. A review of kidney involvement by HLH is provided. (C) 2021 The Authors. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.

引用

页数：6

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