Insight into Potential Biomedical Application of Mesoporous Materials

被引:3
作者
Spiridon, Irene Alexandra [1 ]
Caruntu, Irina Draga [2 ]
Spiridon, Iuliana [3 ]
Braescu, Radu [4 ]
机构
[1] Grigore T Popa Univ Med & Pharm, Dept Morpho Funct Sci Pathol 1 1, Iasi 700115, Romania
[2] Grigore T Popa Univ Med & Pharm, Dept Morphofunct Sci Histol 1, Iasi 700115, Romania
[3] Petru Poni Inst Macromol Chem, Aleea Gr Ghica Voda 41A, Iasi 700487, Romania
[4] Grigore T Popa Univ Med & Pharm, Dept Implantol, Removable Prosthesis, Denture Technol, Iasi 700115, Romania
关键词
mesoporous materials; biomedical applications; drug delivery; imaging; SILICA NANOPARTICLES; DRUG-DELIVERY; MAGNETIC-RESONANCE; CONTROLLED-RELEASE; CARBON NANOTUBES; BREAST-CANCER; SURFACE FUNCTIONALIZATION; SYNTHESIS STRATEGIES; OXIDE NANOPARTICLES; CONTRAST AGENTS;
D O I
10.3390/pharmaceutics14112382
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The physicochemical properties of many drugs have a decisive impact on their bioavailability, as well as the pharmacokinetic efficiency in various disease therapeutics. That is why mesoporous materials have attracted a special interest in the drug delivery field, facilitating the loading of drugs into their pores due to their high surface area and porosity. The interfacial interactions established with drug molecules represent the driving force for efficient drug loading and controlled release kinetics. Moreover, these materials offer an optimal design for implantable local-delivery devices or for improving the accuracy of imaging techniques in clinical diagnosis. Their use is validated by improvements in therapeutic outcome and prevention of side effects. This review discusses the role of mesoporous materials in different biomedical applications.
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页数:24
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