Synthesis of Some New Polyfunctionalized Pyridines

被引：22

作者：

Amer, A. A. ^{[1
]}

机构：

[1] Sohag Univ, Fac Sci, Dept Chem, Sohag 82524, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 01期

关键词：

AGENTS; DERIVATIVES; ANALOGS;

D O I：

10.1002/jhet.3049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Methyl-2,4-dihydro-3H-pyrazol-3-one and/or 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one was reacted with arylidenemalononitrile in the presence of sodium alkoxide to give 2-amino-6-alkoxy-4-arylpyridine-3,5-dicarbonitrile 4a-e instead of the reported pyrazolo[3,4-b]pyridine-5-carbonitriles. The same products 4a-e were prepared via reaction of arylidenemalononitrile with sodium alkoxide in an appropriative alcohol. However, the new synthetic route for preparation of their positional isomer 4-amino-6-alkoxy-2-arylpyridine-3,5-dicarbonitrile 7a-j has been achieved via reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile with different aromatic aldehydes under the same conditions.

引用

页码：297 / 301

页数：5

共 20 条

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