Synthesis of Functionalized Indolizines via Copper-Catalyzed Annulation of 2-Alkylazaarenes with α,β-Unsaturated Carboxylic Acids

被引：125

作者：

Yang, Yuzhu ^{[1
]}

Xie, Chunsong ^{[1
]}

Xie, Yongju ^{[1
]}

Zhang, Yuhong ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 04期

关键词：

PYRROLE-CONTAINING HETEROCYCLES; C-H BOND; EFFICIENT SYNTHESIS; 2-METHYL AZAARENES; CYCLOISOMERIZATION; ALKALOIDS; ACTIVATION; ARYLATION; ENTRY;

D O I：

10.1021/ol300067h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel copper-catalyzed annulation of 2-alkylazaarenes with alpha,beta-unsaturated carboxylic acids has been accomplished. This reaction featuring C-H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materials.

引用

页码：957 / 959

页数：3

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