Na+/K+-ATPase Activation by cAMP in the Midgut of Lutzomyia longipalpis (Lutz & Neiva, 1912; Diptera: Psychodidae)

被引：2

作者：

Nepomuceno, Denise Barguil ^{[1
]}

DAvila Pessoa, Grasielle Caldas ^{[1
]}

Araujo, Ricardo Nascimento ^{[1
]}

Koerich, Leonardo Barbosa ^{[1
]}

Viana Sant'Anna, Mauricio Roberto ^{[1
]}

Pereira, Marcos Horacio ^{[1
]}

Gontijo, Nelder Figueiredo ^{[1
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Dept Parasitol ICB, Lab Fisiol Insetos Hematofagos, Belo Horizonte, MG, Brazil

来源：

JOURNAL OF INSECT SCIENCE | 2022年 / 22卷 / 02期

关键词：

sandfly; Na+; K+-ATPase; cAMP; midgut; pH; PH CONTROL; V-ATPASE; MECHANISMS; H+; TRANSPORTERS; PHYSIOLOGY; MOSQUITO; FAMILY; K+;

D O I：

10.1093/jisesa/ieac008

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Lutzomyia longipalpis (Lutz & Neiva, 1912) females have been intensively studied regarding the regulation of midgut pH. The mechanisms involved in pH regulation are complex, and some aspects remain to be clarified. Here, we investigated the role of the Na+/K+-ATPase pump as an electrochemical potential generator and its modulation by the second messenger cAMP in the midgut of female L. longipalpis. Our results suggest that not only may Na+/K+-ATPase be the main generator of an electrochemical potential across membranes in the midgut of female L. longipalpis, but also its activity is positively regulated by cAMP. cAMP-mediated Na+/K+-ATPase pump activity might be necessary to maintain the transport of the nutrients produced during blood digestion.

引用

页数：4

共 26 条

[1] The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis
Boll, M
Daniel, H
Gasnier, B
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2004, 447 (05): : 776 - 779
[2] Molecular basis of essential amino acid transport from studies of insect nutrient amino acid transporters of the SLC6 family (NAT-SLC6)
Boudko, Dmitri Y.
[J]. JOURNAL OF INSECT PHYSIOLOGY, 2012, 58 (04) : 433 - 449
[3] Characterization of a blood-meal-responsive proton-dependent amino acid transporter in the disease vector, Aedes aegypti
Evans, Amy M.
Aimanova, Karlygash G.
Gill, Sarjeet S.
[J]. JOURNAL OF EXPERIMENTAL BIOLOGY, 2009, 212 (20) : 3263 - 3271
[4] Gill SS, 1998, ARCH INSECT BIOCHEM, V37, P80, DOI 10.1002/(SICI)1520-6327(1998)37:1<80::AID-ARCH10>3.0.CO
[5] 2-6
[6] Lutzomyia longipalpis:: pH in the gut, digestive glycosidases, and some speculations upon Leishmania development
Gontijo, NF
Almeida-Silva, S
Costa, FF
Mares-Guia, ML
Williams, P
Melo, MN
[J]. EXPERIMENTAL PARASITOLOGY, 1998, 90 (03) : 212 - 219
[7] Voltage coupling of primary H+ V-ATPases to secondary Na+- or K+-dependent transporters
Harvey, William R.
[J]. JOURNAL OF EXPERIMENTAL BIOLOGY, 2009, 212 (11) : 1620 - 1629
[8] Vacuolar H+-ATPases: Intra- and intermolecular interactions
Huss, Markus
Vitavska, Olga
Albertmelcher, Andrea
Bockelmann, Svenja
Nardmann, Christin
Tabke, Katharina
Tiburcy, Felix
Wieczorek, Helmut
[J]. EUROPEAN JOURNAL OF CELL BIOLOGY, 2011, 90 (09) : 688 - 695
[9] Effect of cAMP on the activity and the phosphorylation of Na+,K+-ATPase in rat thick ascending limb of Henle
Kiroytcheva, M
Cheval, L
Carranza, ML
Martin, PY
Favre, H
Doucet, A
Féraille, E
[J]. KIDNEY INTERNATIONAL, 1999, 55 (05) : 1819 - 1831
[10] INTRACELLULAR REGULATION OF ION CHANNELS IN CELL-MEMBRANES
LEWIS, DL
LECHLEITER, JD
KIM, D
NANAVATI, C
CLAPHAM, DE
[J]. MAYO CLINIC PROCEEDINGS, 1990, 65 (08) : 1127 - 1143

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