DEVELOPMENT OF A KILOGRAM-SCALE SYNTHESIS OF SALIDROSIDE AND ITS ANALOGS

被引：25

作者：

Shi, Tianyao ^{[2
]}

Chen, Hui ^{[2
]}

Jing, Linlin ^{[2
]}

Liu, Xueying ^{[1
]}

Sun, Xiaoli ^{[2
]}

Jiang, Ru ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Dept Med Chem & Pharmaceut Anal, Sch Pharm, Xian 710032, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Dept Chem, Sch Pharm, Xian 710032, Shaanxi, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Kilogramscale; salidroside; synthesis; tyrosol glycoside; RHODIOLA-ROSEA; PERFORMANCE; EXTRACT;

D O I：

10.1080/00397911.2010.515332

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, safe, and viable process has been developed for large-scale preparation of salidroside, a natural product. The process consists of two chemical steps, which produce the salidroside on a multikilogram scale with 72% overall yield and >98% purity. A series of novel salidroside analogs were prepared according to the same method.

引用

页码：2594 / 2600

页数：7

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