Solubilization of Progesterone and its Derivatives into Gemini Surfactant Solutions

被引：6

作者：

Ideguchi, Hiroki ^{[1
]}

Takasaki, Yuya ^{[1
]}

Kondo, Shintaro ^{[1
]}

Nakanose, Mai ^{[1
]}

Teradahira, Nana ^{[1
]}

Yamamoto, Yumeka ^{[1
]}

Mouri, Umi ^{[1
]}

Nakahara, Hiromichi ^{[1
]}

机构：

[1] Daiichi Univ Pharm, Dept Ind Pharm, Minami Ku, 22-1 Tamagawa Cho, Fukuoka 8158511, Japan

来源：

JOURNAL OF OLEO SCIENCE | 2020年 / 69卷 / 06期

关键词：

progesterone; gemini surfactant; solubilization; micelle; N-ALKYLBENZENES; SPACER; HYDROCORTISONE; MICELLES; BEHAVIOR; THERAPY;

D O I：

10.5650/jos.ess20007

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The solubilization of poorly water-soluble progesterone derivatives into micelles of a gemini surfactant was investigated in an aqueous medium. The aqueous solubility at different temperatures was determined spectroscopically using an ultraviolet visible light spectrophotometer. Thermodynamic parameters for the solubilization were calculated under the basis of the solubility change against temperature. The solubility of progesterone was quite low and remained constant below the critical micelle concentration (cmc) of the surfactant. On the other hand, the solubility increased considerably with increasing surfactant concentration above the cmc. It was suggested that the solubilizates were located in the vicinity of polar regions of micelles.

引用

页码：557 / 562

页数：6

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